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ITX3

Catalog No. T15602 CAS 347323-96-0

ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.

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ITX3, CAS 347323-96-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 59.00
10 mg	In stock	$ 109.00
25 mg	In stock	$ 239.00
50 mg	In stock	$ 465.00
100 mg	In stock	$ 668.00

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Purity: 99.02%

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Description	ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in PC12 cells and REF52 fibroblast structure formation induced by trion.
Targets&IC50	TrioN:76 μM
In vitro	TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)–stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose-dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2].

Molecular Weight	371.45
Formula	C22H17N3OS
CAS No.	347323-96-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.8 mg/mL (4.8 mM), Sonification and heating to 80℃ are recommended.

References and Literature

1. Bouquier N, Vignal E, Charrasse S, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009;16(6):657-666. 2. Yano T, Yamazaki Y, Adachi M, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011;193(2):319-33

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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YH-306 Rac1 Inhibitor W56 acetate(1095179-01-3 free base) SAR407899 ZINC69391 EHop-016 CCG-203971 Z62954982 CCG-257081

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Keywords

ITX3 347323-96-0 Cell Cycle/Checkpoint Others Rho ITX-3 ITX 3 inhibitor inhibit

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