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Ibutamoren Mesylate

Catalog No. T7112 CAS 159752-10-0

Synonyms: MK-0677, MK-677

Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ibutamoren Mesylate, CAS 159752-10-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 57.00
10 mg	In stock	$ 77.00
50 mg	In stock	$ 107.00
100 mg	In stock	$ 127.00
500 mg	In stock	$ 177.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98%

Biological Description

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Description

Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.

In vivo

Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release.?Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).?MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release.?By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue.?The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release.?Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained.?The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release[1].

Synonyms	MK-0677, MK-677
Molecular Weight	624.77
Formula	C28H40N4O8S2
CAS No.	159752-10-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (80.03 mM)

References and Literature

1. Smith R G , Pong S S , Hickey G , et al. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland[J]. Recent Progress in Hormone Research, 1996, 51:261-85; discussion 285-6. 2. Aydemir M , Durap F , Kayan C , et al. Insulin-Like Growth Factor-1 and Growth Hormone (GH) Levels in Canine Cerebrospinal Fluid are Unaffected by GH or GH Secretagogue (MK-0677) Administration[J]. Hormone and Metabolic Research, 1999, 31(02/03):133-137.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Orally Active Compound Library Clinical Compound Library NO PAINS Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

TM-N1324 Capromorelin Tartrate NF-56-EJ40 hydrochloride AnaMorelin hydrochloride Emoghrelin Human growth hormone-releasing factor acetate CJC-1295 acetate(863288-34-0 free base) PF-5190457

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ibutamoren Mesylate 159752-10-0 GPCR/G Protein GHSR MK0677 MK-0677 MK677 Inhibitor Ibutamoren inhibit Growth hormone secretagogue receptor MK 0677 MK-677 MK 677 inhibitor

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