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Isoangustone A

Catalog No. TN4263 CAS 129280-34-8

Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-ÎºB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.

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Isoangustone A, CAS 129280-34-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	422.47
Formula	C25H26O6
CAS No.	129280-34-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Related Products

Related compounds with same targets

Picrasidine I Nortrachelogenin Isodunnianol Isoangustone A Cristacarpin Cimidahurinine Syringaresinol Silybin B

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isoangustone A 129280-34-8 MAPK信号通路 NF-Kb信号通路 PI3K/Akt/mTOR信号通路蛋白酶体干细胞免疫与炎症细胞骨架细胞周期 ROS PI3K Akt CDK NF-κB JNK MMP GSK-3 Inhibitor inhibitor inhibit

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