Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
Description | Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. |
Molecular Weight | 422.47 |
Formula | C25H26O6 |
CAS No. | 129280-34-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Isoangustone A 129280-34-8 MAPK信号通路 NF-Kb信号通路 PI3K/Akt/mTOR信号通路 蛋白酶体 干细胞 免疫与炎症 细胞骨架 细胞周期 ROS PI3K Akt CDK NF-κB JNK MMP GSK-3 Inhibitor inhibitor inhibit