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KGP94

Catalog No. T27730 CAS 1131456-28-4

Synonyms: KGP-94, KGP 94

KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

KGP94, CAS 1131456-28-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00
500 mg	In stock	$ 2,570.00
1 mL * 10 mM (in DMSO)	In stock	$ 272.00

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Purity: 98.52%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.
In vitro	The novel cathepsin L/K inhibitors KGP94 could inhibit in vitro M2 macrophage invasion and reduce the macrophage-stimulated invasion of 4T1 murine breast cancer cells. KGP94 treatment also reduced the expression of several M2-associated markers, suggesting that cathepsin L activity may be important for IL-4-driven M0 to M2 differentiation[1].

Synonyms	KGP-94, KGP 94
Molecular Weight	350.23
Formula	C14H12BrN3OS
CAS No.	1131456-28-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (171.32 mM)

References and Literature

1. Dykes SS, Fasanya HO, Siemann DW. Cathepsin L secretion by host and neoplastic cells potentiates invasion. Oncotarget. 2019 Sep 17;10(53):5560-5568. 2. Sudhan DR, et al. Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94. Clin Exp Metastasis. 2016 Jun;33(5):461-73. 3. Sudhan DR, et al. Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model. Int J Cancer. 2016 Jun 1;138(11):2665-77. 4. Sudhan DR, Siemann DW. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013 Oct;30(7):891-902.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Protease Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

(S)-(+)-Ibuprofen Cathepsin Inhibitor 1 (1S,2R)-Alicapistat Esomeprazole L-006235 ONO-5334 LHVS GLPG2451

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KGP94 1131456-28-4 Proteases/Proteasome Cysteine Protease KGP-94 Inhibitor M2 marker KGP 94 Metastasis Raw264.7 macrophage metastatic carcinoma Cathepsin inhibit prostate (PC-3ML) Cathepsin L breast cancer cell inhibitor

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