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KY-05009

Catalog No. T11793 CAS 1228280-29-2

KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity of Wnt target genes, and promotes apoptosis in cancer cells, displaying anti-cancer properties. Furthermore, it functions as an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM.

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KY-05009, CAS 1228280-29-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 123.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 432.00
100 mg	In stock	$ 622.00
500 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98.06%

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Storage & Solubility Information

Description	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity of Wnt target genes, and promotes apoptosis in cancer cells, displaying anti-cancer properties. Furthermore, it functions as an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM.
Targets&IC50	TNIK:100 nM (ki)
In vitro	KY-05009 (1-3 μM; 48-72 hours; RPMI8226 cells) treatment induces caspase-dependent apoptosis in RPMI8226 cells in a dose-dependent manner. KY-05009 (3 μM; 1 hour; RPMI8226 cells) treatment suppresses the transcriptional activity of Wnt signaling-related genes, including TNIK, CTNNB1, TCF7, and TCF4. KY-05009 (3 μM; 9 hours; RPMI8226 cells) treatment inhibits the IL-6-induced interaction between TCF4 and β-catenin and the phosphorylation of TCF4.KY-05009 (0.1-30 μM; 24 hours; RPMI8226 cells) treatment inhibits the proliferation of RPMI8226 cells in a dose-dependent manner.

Molecular Weight	352.41
Formula	C18H16N4O2S
CAS No.	1228280-29-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (236.46 mM), Sonification is recommended.

References and Literature

1. Lee Y, et al. Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells. Oncotarget. 2017 Jun 20;8(25):41091-41101.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library TGF-beta/Smad Compound Library Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Anti-Colorectal Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compound Library Neuronal Differentiation Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

MSAB Wnt pathway activator 2 CHIR-99021 NRX-103095 Excisanin A FIDAS-3 Kirenol NRX-252114

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Keywords

KY-05009 1228280-29-2 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin plasma-cells KY05009 MAP4K Apoptosis TNIK inhibit anti-cancer Wnt caspase-dependent MAPK Kinase Kinase Kinase anti-proliferative IL-6 KY 05009 Inhibitor smyeloma aminothiazole inhibitor

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