Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.
Description | Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively. |
Targets&IC50 | CSF1R:2 nM, VEGFR2:12 nM |
In vitro | Ki20227 hasn't inhibition for other kinases tested, such as EGFR, Fms-like tyrosine kinase-3, or c-Src (c-src proto-oncogene product). Ki20227 also inhibits the M-CSF-dependent growth of M-NFS-60 cells but not the M-CSF-independent growth of A375 human melanoma cells in vitro. Ki20227 has an inhibition against M-CSF-dependent reactions, such as lipopolysaccharide-induced TNF-α production, which was enhanced by M-CSF in vitro. |
In vivo | Ki20227 reduces the number of tartrate-resistant acid phosphatase-positive osteoclast-like cells on bone surfaces in ovariectomized (ovx) rats. Furthermore, in the Ki20227-treated mice, the number of CD11b(+), Gr-1(+), and Ly-6 g(+) cells in the spleen were decreased and the CII-induced cytokine production in splenocytes isolated from the Ki20227-treated arthritic mice was also reduced. In EAE animal model, Ki20227 inhibits the turn-over/expansion of myeloid cells provoked by the immunization and subsequent MOG-specific T cell responses. |
Synonyms | N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲 |
Molecular Weight | 480.54 |
Formula | C24H24N4O5S |
CAS No. | 623142-96-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 7.2 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ki20227 623142-96-1 蛋白酪氨酸激酶 血管生成 c-Fms c-Kit CSF-1R PDGFR VEGFR inhibit Vascular endothelial growth factor receptor CD117 CSF1R SCFR Ki 20227 colony stimulating factor 1 receptor CSF-1 receptor Platelet-derived growth factor receptor Ki-20227 Inhibitor inhibitor