Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 657.00 | |
100 mg | In stock | $ 918.00 | |
500 mg | In stock | $ 1,830.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 147.00 |
Description | Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response. |
In vitro | Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. METHODS AND RESULTS:Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, Kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay. |
Source |
Molecular Weight | 438.51 |
Formula | C26H30O6 |
CAS No. | 34981-26-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (125.42 mM)
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Kurarinone 34981-26-5 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling NF-Κb Others Stem Cells JAK STAT IκB/IKK BCL NF-κB TNF inhibit Inhibitor inhibitor