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L755507

Catalog No. T6872 CAS 159182-43-1

L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）.

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L755507, CAS 159182-43-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
5 mg	In stock	$ 109.00
10 mg	In stock	$ 176.00
25 mg	In stock	$ 313.00
50 mg	In stock	$ 468.00
100 mg	In stock	$ 673.00
1 mL * 10 mM (in DMSO)	In stock	$ 142.00

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Purity: 99.88%

Purity: 99.04%

Purity: 99%

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Storage & Solubility Information

Description	L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）.
Targets&IC50	β3-adrenoceptor:35 nM
In vitro	L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3].
In vivo	Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2].

Molecular Weight	584.73
Formula	C30H40N4O6S
CAS No.	159182-43-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 58.5 mg/mL (100 mM)

Ethanol: 58.5 mg/mL (100 mM)

References and Literature

1. Parmee ER, et al. Bioorg Med Chem Lett. 1998, 8(9):1107-1112. 2. Fisher MH, et al. J Clin Invest. 1998, 101(11): 2387–2393. 3. Yu C, et al. Cell Stem Cell. 2015, 16(2):142-147. 4. Sato M, et al. Mol Pharmacol. 2008, 74(5):1417-1428.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Anti-Hypertension Compound Library Preclinical Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library Endocrinology-Hormone Compound Library Neuronal Signaling Compound Library Anti-Cardiovascular Disease Compound Library

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Keywords

L755507 159182-43-1 DNA Damage/DNA Repair GPCR/G Protein Neuroscience CRISPR/Cas9 Adrenergic Receptor HDR β3-AR inhibit Beta Receptor Inhibitor L-755507 L 755507 inhibitor

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