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LH846

Catalog No. T1877 CAS 639052-78-1

Synonyms: LH 846, LH-846

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.

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LH846, CAS 639052-78-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 58.00
10 mg	In stock	$ 79.00
25 mg	In stock	$ 148.00
50 mg	In stock	$ 247.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 98.13%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.
Targets&IC50	CK1ε:1.3 μM, CK1α:2.5 μM, CK1δ:290 nM

Synonyms	LH 846, LH-846
Molecular Weight	316.81
Formula	C16H13ClN2OS
CAS No.	639052-78-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lee JW, et al. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11.

Related compound libraries

This product is contained In the following compound libraries：

Metabolism Compound Library Inhibitor Library Kinase Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

PF-5006739 CKI-7 free base Ellagic acid (hydrate) IC261 XL413 hydrochloride D4476 A-3 hydrochloride LY294002

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LH846 639052-78-1 Metabolism Stem Cells Casein Kinase LH 846 inhibit Inhibitor LH-846 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.