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LM11A-31 dihydrochloride

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Catalog No. T11861Cas No. 1243259-19-9

LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.

LM11A-31 dihydrochloride

LM11A-31 dihydrochloride

🥰Excellent
Catalog No. T11861Cas No. 1243259-19-9
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.
Pack SizePriceAvailabilityQuantity
10 mg$38In Stock
25 mg$82In Stock
50 mg$121In Stock
100 mg$221In Stock
200 mg$332In Stock
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Purity:≥98%
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Product Introduction

Bioactivity
Description
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist.
In vivo
LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].?LM11A-31 (oral gavage;?50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].
Chemical Properties
Molecular Weight316.27
FormulaC12H27Cl2N3O2
Cas No.1243259-19-9
SmilesCl.Cl.CC[C@H](C)[C@H](N)C(=O)NCCN1CCOCC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 125 mg/mL (395.23 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.1619 mL15.8093 mL31.6186 mL158.0928 mL
5 mM0.6324 mL3.1619 mL6.3237 mL31.6186 mL
10 mM0.3162 mL1.5809 mL3.1619 mL15.8093 mL
20 mM0.1581 mL0.7905 mL1.5809 mL7.9046 mL
50 mM0.0632 mL0.3162 mL0.6324 mL3.1619 mL
100 mM0.0316 mL0.1581 mL0.3162 mL1.5809 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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