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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T17870 | CIAP1 ligand 1 | E3 ligase Ligand 12 | Others |
cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used to couple with androgen receptor ligands ... | |||
T10053 | 5HT6-ligand-1 | 5-HT Receptor | |
5HT6-ligand-1 is an orally active ligand of 5-HT6 receptor (Ki = 1.43 nM). | |||
TP1484L | α2β1 Integrin Ligand Peptide acetate | α2β1 Integrin Ligand Peptide acetate (134580-64-6) | Integrin |
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor. α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the... | |||
T13510 | Sigma-LIGAND-1 | Sigma receptor | |
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor. | |||
T5835 | PROTAC ERRα ligand 2 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM) | |||
T15191 | PROTAC ERRα ligand 1 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively). | |||
T12551 | PROTAC BRD4 ligand-1 | Epigenetic Reader Domain , Ligands for Target Protein for PROTAC | |
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET. | |||
T17879 | E3 ligase Ligand 8 | Others , Ligand for E3 Ligase | |
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoti... | |||
TP1704 | Galanin Receptor Ligand M35 TFA | Neuropeptide Y Receptor | |
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). | |||
T38476 | Metallo β-lactamase ligand 1 | Antibacterial | |
Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities. | |||
T60015 | TSPO ligand-2 | Carbonic acid | AUTACs |
TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety. | |||
T9809 | E3 ligase Ligand 23 | Ligand for E3 Ligase | |
E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome. | |||
TP1496L | P5 Ligand for Dnak and DnaJ acetate | p5 Ligand for Dnak and DnaJ acetate(209518-24-1 free base) | HSP |
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40). | |||
T13848 | SMARCA-BD ligand 1 for Protac | Epigenetic Reader Domain | |
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2 | |||
T9360 | CRBN ligand-9 | 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione | Ligand for E3 Ligase |
CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN. | |||
T13890 | SMARCA-BD ligand 1 for Protac dihydrochloride | Epigenetic Reader Domain | |
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC. | |||
T73599 | TSPO ligand-1 | Autophagy | |
TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.TSPO ligand-1 is an AUTAC4-binding protein in the transmembrane domain of the outer mitochondrial membrane, which induces mitochondrial autop... | |||
T39628 | PROTAC BRD4 ligand-2 | PROTAC BRD4 ligand-2 | |
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. | |||
T39997 | PROTAC CDK9 ligand-1 | PROTAC CDK9 ligand-1 | |
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs. | |||
T82174 | HRIO2 kinase ligand-1 | Others | |
hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM). | |||
T39629 | BRD4 ligand-Linker Conjugate 1 | BRD4 ligand-Linker Conjugate 1 | |
BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules uti... | |||
T17869 | CIAP1 ligand 2 | E3 ligase Ligand 11 | Others |
cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER. | |||
T39609 | CIAP1 Ligand-Linker Conjugates 16 | cIAP1 Ligand-Linker Conjugates 16 | |
cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs. | |||
T39440 | CXCL12 ligand 1 | ||
CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 . | |||
T40142 | Thalidomide-NH-CBP/p300 ligand 2 | Thalidomide-NH-CBP/p300 ligand 2 | |
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440). | |||
T40144 | CBP/p300 ligand 2 | ||
CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP. | |||
T17895 | CIAP1 Ligand-Linker Conjugates 1 | E3 ligase Ligand-Linker Conjugates 41 | Others |
cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1]. | |||
T17892 | CIAP1 Ligand-Linker Conjugates 12 | E3 ligase Ligand-Linker Conjugates 38 | Others |
cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creatin... | |||
T17897 | CIAP1 Ligand-Linker Conjugates 13 | E3 ligase Ligand-Linker Conjugates 43 | Others |
cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1]. | |||
T17899 | CIAP1 Ligand-Linker Conjugates 9 | E3 ligase Ligand-Linker Conjugates 45 | Others |
cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1]. | |||
T17898 | CIAP1 Ligand-Linker Conjugates 7 | E3 ligase Ligand-Linker Conjugates 44 | Others |
cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1]. | |||
T7763 | Thalidomide-4-OH | Cereblon ligand 2,E3 ligase Ligand 2 | Ligand for E3 Ligase |
Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs | |||
T17364 | AhR Ligand-Linker Conjugates 1 | E3 Ligase Ligand-Linker Conjugates 57 | Others |
AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be ... | |||
T7752 | (S,R,S)-AHPC-Me | VHL ligand 2,E3 ligase Ligand 1A | Ligand for E3 Ligase |
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a... | |||
T17901 | CIAP1 Ligand-Linker Conjugates 10 | E3 ligase Ligand-Linker Conjugates 47 | Others |
cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROT... | |||
T17889 | CIAP1 Ligand-Linker Conjugates 14 | E3 ligase Ligand-Linker Conjugates 36 | Others |
cIAP1 Ligand-Linker Conjugates 14 consist of an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker. These conjugates, known as cIAP1 Ligand-Linker Conjugates 14, are used in the development of SNIPERs[1]... | |||
T17887 | CIAP1 Ligand-Linker Conjugates 15 | E3 ligase Ligand-Linker Conjugates 34 | Others |
cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1... | |||
T17896 | CIAP1 Ligand-Linker Conjugates 4 | E3 ligase Ligand-Linker Conjugates 42 | Others |
cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potenti... | |||
T17885 | CIAP1 Ligand-Linker Conjugates 11 | E3 ligase Ligand-Linker Conjugates 33 | Others |
cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in ... | |||
T17900 | CIAP1 Ligand-Linker Conjugates 8 | E3 ligase Ligand-Linker Conjugates 46 | Others |
cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1]. | |||
T17916 | Pomalidomide-PEG4-C2-NH2 | Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22 | Others , Ligand for E3 Ligase |
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and 4-unit PEG linker. | |||
T17893 | CIAP1 Ligand-Linker Conjugates 5 | E3 ligase Ligand-Linker Conjugates 39 | Others |
cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for... | |||
T17894 | CIAP1 Ligand-Linker Conjugates 3 | E3 ligase Ligand-Linker Conjugates 40 | Others |
cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find ... | |||
T17891 | CIAP1 Ligand-Linker Conjugates 2 | E3 ligase Ligand-Linker Conjugates 37 | Others |
cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1]. | |||
T17908 | VHL Ligand-Linker Conjugates 15 | E3 Ligase Ligand-Linker Conjugates 56 | Others |
VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1]. | |||
T72013 | Epigenetic Multiple Ligand | ||
Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing e... | |||
T13671 | (S,R,S)-AHPC-Me hydrochloride | VHL ligand 2 hydrochloride,E3 ligase Ligand 1 | Others , Ligand for E3 Ligase |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell... | |||
T15189 | Thalidomide-O-amido-C4-N3 | E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4 | Others , Ligand for E3 Ligase |
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker. | |||
T13958 | VHL Ligand 8 | Others | |
VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive p... | |||
T7753 | Thalidomide-O-COOH | Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 | Others , Ligand for E3 Ligase |
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T24729 | Roseoflavin | Antibacterial | |
Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis. | |||
TQ0176 | (-)-Isocorypalmine | Tetrahydrocolumbamine,(S)-Tetrahydrocolumbamine | Dopamine Receptor , Antifungal |
(-)-Isocorypalmine ((S)-Tetrahydrocolumbamine), a natural product isolated from Corydalis chaerophylla, has significant antifungal activity. | |||
T8097 | Methyl 3-aminopropanoate hydrochloride | β-Alanine methyl ester hydrochloride | Others |
Methyl 3-aminopropanoate hydrochloride (β-Alanine methyl ester hydrochloride) is the ethyl ester of the non-essential amino acid β-alanine. | |||
T14063 | 7α,25-Dihydroxycholesterol | 7α,25-OHC | EBI2/GPR183 , Endogenous Metabolite |
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cel... | |||
T4S0039 | Baimaside | Quercetin-3-O-sophoroside,Quercetin 3-beta-D-sophoroside | Others |
Baimaside (Quercetin-3-O-sophoroside) is the natural ligand of Bet v 1. | |||
T13815 | Penicillic acid | Apoptosis , Caspase , Antibacterial , Antibiotic | |
Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitr... | |||
TP1232L | Amylin, amide, rat acetate(124447-81-0,free base) | Amylin Receptor | |
Amylin, amide, rat acetate is a potent and high affinity ligand of AMY1 and AMY3 receptors and variably of AMY2 receptors. | |||
T3806 | Kaempferide | Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Influenza Virus , Antibacterial , Autophagy |
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activatio... | |||
TN2077 | (+/-)-Pinocembrin | NSC 43318,(±)-5,7-Dihydroxyflavanone | GPR , Others |
(+/-)-Pinocembrin (NSC-43318), a natural product from axillary pines, is a GPR120 ligand that promotes wound healing in the HaCaT cell line. | |||
T8363 | DL-Serine | PKM | |
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. | |||
TN1023 | Miltirone | P450 , GABA Receptor | |
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors. | |||
Fr12596 | 3-Acetylcoumarin | Others | |
3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties. | |||
T5026 | Oxytocin | α-Hypophamine,Oxytocic hormone,Oxytocin (Syntocinon) | Oxytocin Receptor |
Oxytocin (Oxytocin (Syntocinon)) is a mammalian neurohypophysial hormone, a ligand of oxytocin receptor. | |||
TJS1183 | Cyclen | 1,4,7,10-tetraazacyclododecane | Others |
Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents. | |||
TN3209 | 3′,4′,7-Trihydroxyflavone | ATPase , Others , p38 MAPK , NF-κB | |
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclasto... | |||
T5145 | Oxytocin acetate | Oxytocic hormone acetate,α-Hypophamine acetate,Oxytocin acetate (50-56-6 free base) | Oxytocin Receptor |
Oxytocin acetate (α-Hypophamine acetate) is a mammalian neurohypophysial hormone, a ligand of oxytocin receptor. | |||
T3S0738 | Yangonin | Y100550 | Cannabinoid Receptor , NF-κB , Autophagy |
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate for the intervention of NF-κB-dependent pathological conditio... | |||
T36857 | Estrone sulfate sodium | Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate | Endogenous Metabolite |
Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigate... | |||
T15705 | Laminaran | β-1,3-Glucan | |
Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by gluca... | |||
T7998 | 1,7-Diaminoheptane | Others | |
1,7-Diaminoheptane is a compound of the aliphatic amine family. It is used in the synthesis of peptides, peptidomimetics, and other compounds, and has also been used as a substrate in enzyme reactions, as a ligand in met... | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
T0034 | Cortisone acetate | Cortisone 21-acetate,NSC 49420 | Glucocorticoid Receptor , Endogenous Metabolite |
Cortisone Acetate is a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate (NSC-49420) d... | |||
TL0005 | 3,5-O-Dicaffeoylquinic acid | Isochlorogenic Acid A,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid | Others |
3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. ... | |||
TN6694 | 5,6-Benzoflavone | β-Naphthoflavone,beta-NF | Antioxidant |
5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a... | |||
T2915 | Bardoxolone | RTA 401,CDDO | Others , Nrf2 |
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp... | |||
T1168 | Desonide | Tridesilon,Locapred,Prednacinolone | Glucocorticoid Receptor |
Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated ... | |||
T4S0498 | Glaucocalyxin A | Wangzaozin B,Leukamenin F | Apoptosis , Akt , Caspase , PI3K |
1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi... | |||
T37974 | (S)-Coriolic acid | 13(S)-HODE | Lipoxygenase , Mitochondrial Metabolism , PPAR |
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation i... | |||
T0798 | Triamcinolone | Fluoxyprednisolone,Aristocort,Rodinolone | Glucocorticoid Receptor , COX |
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca... | |||
T14011 | 2-Arachidonoylglycerol | Cannabinoid Receptor , Endogenous Metabolite | |
In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand | |||
T4938 | Potassium 1H-indol-3-yl sulfate | Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate | AhR , Endogenous Metabolite |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm... | |||
T38468 | Glycodeoxycholic acid monohydrate | ||
Glycodeoxycholic acid monohydrate is a nuclear receptor ligand. | |||
T13735 | Imidazoleacetic acid | Imidazolyl-4-acetic acid | Others |
Imidazoleacetic acid, an endogenous ligand, stimulates imidazole receptors. | |||
T10821 | Cirsiliol | Lipoxygenase | |
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors. | |||
TN4628 | Nelumol A | FXR | |
Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists. | |||
T16846 | Sauristolactam | Saurolactam | Others |
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated f... | |||
T82578 | Desacetylxanthanol | ||
Desacetylxanthanol (Compound 4), a sesquiterpenoid originating from Xanthium strumarium, exhibits anti-tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) activity [1]. | |||
T75682 | Cortisol sulfate | ||
Cortisol sulfate (Cortisol 21-sulfate) is a metabolite of Cortisol . Cortisol sulfate is a specific ligand for intracellular transcortin [1] [2] [3] . | |||
TN1484 | Cheilanthifoline | NF-κB , Antifection | |
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated... | |||
TN3537 | Braylin | IL Receptor , TNF , NF-κB | |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also ... | |||
T82572 | D-Glucosyl-β-1,1′-N-palmitoylsphingosine | C16 Glucosyl(β) Ceramide (d18:1/16:0) | |
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) serves as an endogenous ligand for the Macrophage-Inducible C-type Lectin (Mincle), exhibiting immunostimulatory properties [1]. | |||
T21500 | Sphingosine-1-phosphate | S1P | Endogenous Metabolite , S1P Receptor , LPL Receptor |
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protei... | |||
T21577 | Narasin (sodium salt) | Naracin sodium salt,naransin sodium,HainanMycin | NF-κB |
Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by suppressing the phosphorylation o... | |||
TN4383 | Kazinol U | IL Receptor , IκB/IKK , NOS , NF-κB | |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-... | |||
TN3539 | Broussonin A | ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt | |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-lucife... | |||
TN2143 | 3,7,4'-Trihydroxyflavone | Resokaempferol,5-Deoxykampferol | DNA |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) is a DNA-breaking flavonoid isolated from rosewood heartwood. It inhibits osteoclast differentiation, actin ring formation, and bone resorption in RAW 264.7 cells and bone marro... | |||
T36563 | (E)-Guggulsterone | ||
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulat... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06873 | FLT3 Ligand Protein, Human, Recombinant | Human | E. coli |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPJ-00139 | 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His) | Human | E. coli |
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain... | |||
TMPY-03215 | FLT3 Ligand Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPY-03066 | FLT3 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPY-01672 | ICOS ligand Protein, Human, Recombinant (His) | Human | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPY-02022 | CD40 Ligand Protein, Human, Recombinant (hFc) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-03956 | Fas Ligand Protein, Human, Recombinant (His) | Human | Yeast |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells su... | |||
TMPY-00033 | 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc) | Human | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as de... | |||
TMPY-03542 | CD40 Ligand Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-04086 | CD40 Ligand Protein, Canine, Recombinant | Canine | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-04065 | CD40 Ligand Protein, Canine, Recombinant (mFc) | Canine | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-03301 | CD40 Ligand Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-04913 | Fas Ligand Protein, Rat, Recombinant (His) | Rat | Yeast |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells su... | |||
TMPY-05332 | FLT3 Ligand Protein, Rat, Recombinant (His) | Rat | Baculovirus-Insect Cells |
FLT3L, also known as flt3 ligand, is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. In vivo, FLT3L also induces the mobilization of th... | |||
TMPY-00329 | ICOS ligand Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPY-00213 | ICOS ligand Protein, Rat, Recombinant (His) | Rat | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPY-04858 | ICOS ligand Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPY-06813 | ICOS ligand Protein, Human, Recombinant | Human | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPH-03201 | CD40 Ligand Protein, Rabbit, Recombinant (His) | Rabbit | Yeast |
CD40 Ligand Protein, Rabbit, Recombinant (His) is expressed in Yeast. | |||
TMPY-04857 | ICOS ligand Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPK-00125 | FLT3 Ligand Protein, Human, Recombinant (hFc) | Human | HEK293 |
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synerg... | |||
TMPJ-00151 | CD40 Ligand Protein, Human, Recombinant | Human | E. coli |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioact... | |||
TMPJ-00432 | GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell res... | |||
TMPJ-00075 | CD27 Ligand/CD70 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand ext... | |||
TMPK-00053 | GITR Ligand/TNFSF18 Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPK-01064 | GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPY-03525 | ICOS ligand Protein, Human, Recombinant (hFc) | Human | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPJ-00150 | CD40 Ligand Protein, Human, Recombinant (Mammalian) | Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioact... | |||
TMPJ-00138 | 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His & Flag) | Human | Human Cells |
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain... | |||
TMPH-03200 | CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His) | Rabbit | E. coli |
CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli. | |||
TMPY-05224 | ICOS ligand Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains an... | |||
TMPY-02993 | 4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (His) | Rat | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as de... | |||
TMPY-05173 | 4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as de... | |||
TMPY-02992 | 4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as de... | |||
TMPY-04587 | Fas Ligand Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells su... | |||
TMPJ-00137 | APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) | Human | Human Cells |
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to relea... | |||
TMPJ-00920 | CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His) | Mouse | Human Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and ... | |||
TMPK-00122 | CD30 Ligand/TNFSF8 Protein, Human, Recombinant (His) | Human | HEK293 |
CD30 ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. The protein is also constitutively expressed... | |||
TMPJ-00153 | CD40 Ligand Protein, Human, Recombinant (His & Flag) | Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioact... | |||
TMPY-05506 | 4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc), Biotinylated | Cynomolgus | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as de... | |||
TMPY-01758 | CD40 Ligand Protein, Human, Recombinant (His) | Human | E. coli |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-06687 | CD40 Ligand Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPY-03645 | BAFF/TNFSF13B Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPK-00079 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His) | Human | HEK293 |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPJ-01470 | SCF Protein, Human, Recombinant | Human | E.coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultu... | |||
TMPK-00666 | CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activa... | |||
TMPY-02793 | CD40 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPJ-00152 | CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioact... | |||
TMPK-00860 | CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc) | Mouse | HEK293 |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w... | |||
TMPK-01398 | CD40 Ligand Trimer Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w... | |||
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L2800 | Serotonin Receptor-Targeted Compound Library | 275 compounds | |
A unique collection of 275 compounds targeting serotonin receptors for high throughput screening and high content screening; | |||
L7400 | Sodium Channel Blocker Library | 128 compounds | |
A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening; | |||
L7200 | Calcium Channel Compound Library | 143 compounds | |
A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening; | |||
L2610 | Neurotransmitter Receptor Compound Library | 1513 compounds | |
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening; |