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NS3861

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Purity:99.40%

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COA HNMR LCMS

NS3861

Catalog No. T9542Cas No. 216853-59-7

NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-containing receptors. The maximal efficacy of NS3861 appeared solely dependent on the nature of the ligand-binding domain. Furthermore, a principal subunit serine to threonine substitution may explain the lack of NS3861 activation at α4-containing receptors.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$72	In Stock
25 mg	$172	In Stock
50 mg	$289	In Stock
100 mg	$463	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description

In vitro

NS3861 was found to activate wild-type α3β4 nAChRs (Figs. 3R and 4) but did not activate wild-type α4β2. Whereas NS3861 was a partial agonist at α3β4, it proved to be a full agonist at α3β2 albeit with ～10-fold lower potency consistent with the binding affinities. Efficacy at the α3/α4 + β4/β2 receptor was almost identical to that of wild-type α3β4, whereas no efficacy could be seen at α4/α3 + β2/β4[1].

Chemical Properties

Molecular Weight	284.22
Formula	C12H14BrNS
Cas No.	216853-59-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (351.84 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5184 mL	17.5920 mL	35.1840 mL	175.9201 mL
5 mM	0.7037 mL	3.5184 mL	7.0368 mL	35.1840 mL
10 mM	0.3518 mL	1.7592 mL	3.5184 mL	17.5920 mL
20 mM	0.1759 mL	0.8796 mL	1.7592 mL	8.7960 mL
50 mM	0.0704 mL	0.3518 mL	0.7037 mL	3.5184 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	1.7592 mL

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