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ZM241385

🥰Excellent
Catalog No. T7021Cas No. 139180-30-6

ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.

ZM241385

ZM241385

🥰Excellent
Purity: 99.69%
Catalog No. T7021Cas No. 139180-30-6
ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
Pack SizePriceAvailabilityQuantity
5 mg49 €In Stock
10 mg71 €In Stock
25 mg128 €In Stock
50 mg232 €In Stock
100 mg432 €In Stock
200 mg652 €In Stock
500 mg1.026 €In Stock
1 mL x 10 mM (in DMSO)49 €In Stock
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Purity:99.69%
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Product Introduction

Bioactivity
Description
ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.
Targets&IC50
A2AR:1.4 nM (Ki)
In vitro
ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7?min) OGD period, and protect CA1 neuron and astrocyte from injury[4].
In vivo
ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1].
Cell Research
Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dWater and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO. (Only for Reference)
Chemical Properties
Molecular Weight337.34
FormulaC16H15N7O2
Cas No.139180-30-6
SmilesNc1nc(NCCc2ccc(O)cc2)nc2nc(nn12)-c1ccco1
Relative Density.1.59 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 1.7 mg/mL (5 mM)
DMSO: 55 mg/mL (163.04 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.9644 mL14.8218 mL29.6437 mL148.2184 mL
5 mM0.5929 mL2.9644 mL5.9287 mL29.6437 mL
DMSO
1mg5mg10mg50mg
10 mM0.2964 mL1.4822 mL2.9644 mL14.8218 mL
20 mM0.1482 mL0.7411 mL1.4822 mL7.4109 mL
50 mM0.0593 mL0.2964 mL0.5929 mL2.9644 mL
100 mM0.0296 mL0.1482 mL0.2964 mL1.4822 mL

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