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SR3335

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Purity:99.41%

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COA HNMR HPLC

SR3335

Catalog No. T5160Cas No. 293753-05-6

SR3335 (ML 176) is a selective inverse agonist of RORα that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).

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Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$128	In Stock
25 mg	$258	In Stock
50 mg	$478	In Stock
100 mg	$689	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	SR3335 (ML 176) is a selective inverse agonist of RORα that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
Targets&IC50	RORα:220 nM(ki)
Alias	ML 176

Chemical Properties

Molecular Weight	405.34
Formula	C13H9F6NO3S2
Cas No.	293753-05-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 30 mg/mL

DMSO: 50 mg/mL (123.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4671 mL	12.3353 mL	24.6706 mL	123.3532 mL
5 mM	0.4934 mL	2.4671 mL	4.9341 mL	24.6706 mL
10 mM	0.2467 mL	1.2335 mL	2.4671 mL	12.3353 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1677 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4671 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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