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Amodiaquine

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Purity:99.78%

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COA HPLC HNMR

Amodiaquine

Catalog No. T8381Cas No. 86-42-0

Amodiaquine is a synthetic aminoquinoline, used to treat malaria.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$44	In Stock
2 mg	$64	In Stock
5 mg	$97	In Stock
10 mg	$183	In Stock
25 mg	$319	In Stock
50 mg	$475	In Stock
100 mg	$682	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Product Introduction

Bioactivity

Description	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
Targets&IC50	Nurr1-LBD (ligand binding domain):20 μM (EC50)
In vitro	Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH).?a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH.?Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes.?Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.?These results suggest that Nurr1 serves a novel target for ICH therapy.

Chemical Properties

Molecular Weight	355.86
Formula	C20H22ClN3O
Cas No.	86-42-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 71 mg/mL (199.52 mM)

Methanol: 50 mg/mL (140.5 mM), Sonification is recommended.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8101 mL	14.0505 mL	28.1009 mL	140.5047 mL
5 mM	0.5620 mL	2.8101 mL	5.6202 mL	28.1009 mL
10 mM	0.2810 mL	1.4050 mL	2.8101 mL	14.0505 mL
20 mM	0.1405 mL	0.7025 mL	1.4050 mL	7.0252 mL
50 mM	0.0562 mL	0.2810 mL	0.5620 mL	2.8101 mL
100 mM	0.0281 mL	0.1405 mL	0.2810 mL	1.4050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc