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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
2 mg | $64 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $183 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $475 | In Stock | |
100 mg | $682 | In Stock | |
1 mL x 10 mM (in DMSO) | $123 | In Stock |
Description | Amodiaquine is a synthetic aminoquinoline, used to treat malaria. |
Targets&IC50 | Nurr1-LBD (ligand binding domain):20 μM (EC50) |
In vitro | Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH).?a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH.?Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes.?Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.?These results suggest that Nurr1 serves a novel target for ICH therapy. |
Molecular Weight | 355.86 |
Formula | C20H22ClN3O |
Cas No. | 86-42-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 71 mg/mL (199.52 mM) Methanol: 50 mg/mL (140.5 mM), Sonification is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Methanol/DMSO
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