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Giredestrant

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Purity:98.96%

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COA HNMR HPLC

Giredestrant

Catalog No. T11399Cas No. 1953133-47-5

Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.

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Pack Size	Price	Availability
1 mg	$139	In Stock
5 mg	$289	In Stock
10 mg	$463	In Stock
25 mg	$868	In Stock
50 mg	$1,390	In Stock
100 mg	$2,180	In Stock
200 mg	$2,960	In Stock
1 mL x 10 mM (in DMSO)	$332	In Stock

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Product Introduction

Bioactivity

Description	Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.
In vitro	The highly potent in vivo efficacy of Giredestrant likely arises due to the particular combination of high binding potency, full suppression of ER signaling, and an improved DMPK profile.Giredestrant (GDC-9545) is a novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes.
Alias	GDC-9545

Chemical Properties

Molecular Weight	522.55
Formula	C27H31F5N4O
Cas No.	1953133-47-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (191.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9137 mL	9.5685 mL	19.1369 mL	95.6846 mL
5 mM	0.3827 mL	1.9137 mL	3.8274 mL	19.1369 mL
10 mM	0.1914 mL	0.9568 mL	1.9137 mL	9.5685 mL
20 mM	0.0957 mL	0.4784 mL	0.9568 mL	4.7842 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9137 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9568 mL

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