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UT-155

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Purity:99.63%

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COA HNMR HPLC

UT-155

Catalog No. T13272Cas No. 2031161-35-8

UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).

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Pack Size	Price	Availability
1 mg	$93	In Stock
2 mg	$137	In Stock
5 mg	$228	In Stock
10 mg	$363	In Stock
25 mg	$583	In Stock
50 mg	$793	In Stock
100 mg	$1,130	In Stock
500 mg	$2,280	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Product Introduction

Bioactivity

Description	UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).
In vitro	UT-155 binds to the AR-LBD (Ki: 267 nM). UT-155 potently inhibits the R1881-induced wildtype AR transactivation with 6-10-fold higher potency than enzalutamide. While UT-155 antagonizes both wildtype and mutant ARs comparably, Compared to wild-type AR, the W742L mutant AR makes enzalutamide twice as weak. Treatment of LNCaP cells with UT-155 can inhibit the expression of PSA and FKBP5 genes induced by 0.1 nM R1881 between 10 and 100 nM, and the efficacy is 5-10 times better than enzalutamide.
In vivo	Consistent with the anti-proliferative effects in vitro, UT-155 significantly inhibits the growth of 22RV1 xenograft by 53%, while, enzalutamide has no effect on the growth of the 22RV1 tumors. In UT-155-treated animals, tumor weights and PSA and the expression of AR and AR-SV are significantly lower.

Chemical Properties

Molecular Weight	405.35
Formula	C20H15F4N3O2
Cas No.	2031161-35-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 130 mg/mL (320.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4670 mL	12.3350 mL	24.6700 mL	123.3502 mL
5 mM	0.4934 mL	2.4670 mL	4.9340 mL	24.6700 mL
10 mM	0.2467 mL	1.2335 mL	2.4670 mL	12.3350 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4670 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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