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LMK-235

Catalog No. T6061 CAS 1418033-25-6

Synonyms: LMK235

LMK-235 is a potent HDAC inhibitor, and is used in cancer research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LMK-235, CAS 1418033-25-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 46.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 142.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 447.00
200 mg	In stock	$ 659.00
500 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.24%

Purity: 98.18%

Purity: 97.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LMK-235 is a potent HDAC inhibitor, and is used in cancer research.
Targets&IC50	HDAC5:4.2 nM, HDAC4:11.9 nM
In vivo	LMK-235 demonstrates significant cytotoxicity against the breast cancer cell line MDA-MB-231, the oral cancer cell line Cal27, and the esophageal cancer cell line Kyse510, notably enhancing the cytotoxic effect of cisplatin. Additionally, LMK-235 exhibits nanomolar-level activity across various life-cycle stages of Plasmodium species. It induces histone deacetylase (HDAC) inhibition in human cancer cell lines with varying sensitivity to cisplatin compounds, achieving an IC50 of less than 1 μM.
Kinase Assay	HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds.
Cell Research	The rate of cell survival under the action of test substances is evaluated by an improved MTT assay. The assay is based on the ability of viable cells to metabolize yellow MTT to violet formazan that can be detected spectrophotometrically. In brief, A2780, Cal27, Kyse510, and MDA-MB-231 cell lines are seeded at a density of 5000, 7000, 8000, and 10 000 cells/well in 96-well plates. After 24 h, cells are exposed to increased concentrations of the test compounds. Incubation is ended after 72 h, and cell survival is determined by addition of MTT solution (5 mg/mL in phosphate buffered saline). The formazan precipitate is dissolved in DMSO. Absorbance s measured at 544 and 690 nm in a FLUOstar microplate reader. (Only for Reference)

Synonyms	LMK235
Molecular Weight	294.35
Formula	C15H22N2O4
CAS No.	1418033-25-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29.4 mg/mL (100 mM)

Ethanol: 29.4 mg/mL (100 mM)

References and Literature

1. Marek L, et al. J Med Chem. 2013, 56(2), 427-436. 2. Hansen FK, et al. Eur J Med Chem. 2014, 82, 204-213.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library Reprogramming Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Anti-Aging Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

Entinostat SKLB-23bb HDAC3-IN-2 Pimelic diphenylamide 106 PRO-HD2 PRO-HD3 AES-350 Trichostatin A

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LMK-235 1418033-25-6 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC LMK 235 Histone deacetylases LMK235 Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.