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LSKL, Inhibitor of Thrombospondin TSP-1 acetate

Catalog No. T7676 CAS T7676

Synonyms: LSKL, Inhibitor of Thrombospondin TSP-1

LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .

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LSKL, Inhibitor of Thrombospondin TSP-1 acetate Chemical Structure

LSKL, Inhibitor of Thrombospondin TSP-1 acetate, CAS T7676

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
2 mg	In stock	$ 62.00
5 mg	In stock	$ 86.00
10 mg	In stock	$ 135.00
25 mg	In stock	$ 248.00
50 mg	In stock	$ 381.00
100 mg	In stock	$ 587.00
1 mL * 10 mM (in DMSO)	In stock	$ 148.00

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Description	LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
In vivo	Administration of LSKL peptide attenuated Smad2 phosphorylation at 6 h. S-phase entry of hepatocytes was accelerated at 24 and 48 h by LSKL peptide, which resulted in faster recovery of the residual liver and bodyweight.?Haematoxylin and eosin tissue staining and blood biochemical examinations revealed no significant adverse effects following the two LSKL peptide administrations.?In the clinical setting, plasma TSP-1 levels were lowest on the first day after hepatectomy.?However, plasma TSP-1 levels at this stage were significantly higher in patients with subsequent liver dysfunction compared with levels in those without liver dysfunction following hepatectomy
Animal Research	Mice were operated on with a 70 per cent hepatectomy or sham procedure. Operated mice received either LSKL peptide or normal saline intraperitoneally at abdominal closure and 6 h after hepatectomy. Perioperative plasma TSP-1 levels were measured by enzyme-linked immunosorbent assay in patients undergoing hepatectomy.

Synonyms	LSKL, Inhibitor of Thrombospondin TSP-1
Molecular Weight	686.64
Formula	C25H44F6N6O9
CAS No.	T7676

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (40.05 mM)

References and Literature

1. Kuroki H , Hayashi H , Nakagawa S , et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model[J]. British Journal of Surgery, 2015, 102(7):813-825.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Anti-Cardiovascular Disease Compound Library Stem Cell Differentiation Compound Library Anti-Fibrosis Compound Library Kinase Inhibitor Library Anti-Colorectal Cancer Compound Library Reprogramming Compound Library Anti-Breast Cancer Compound Library Bioactive Compound Library

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Dorsomorphin Elezanumab Halofuginone hydrobromide SM1-71 ITD-1 Myristoyl tetrapeptide-12 CJJ300 TGFβ-IN-5

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Keywords

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