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LY2090314

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Purity:99.88%

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COA HNMR HPLC

LY2090314

Catalog No. T1755Cas No. 603288-22-8

LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.

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Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$57	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$278	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock

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Product Introduction

Bioactivity

Description	LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
In vivo	LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts. [1]

Chemical Properties

Molecular Weight	512.53
Formula	C28H25FN6O3
Cas No.	603288-22-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (181.5 mM)

Ethanol: 2 mg/mL (3.9 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.9511 mL	9.7555 mL	19.5111 mL	97.5553 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3902 mL	1.9511 mL	3.9022 mL	19.5111 mL
10 mM	0.1951 mL	0.9756 mL	1.9511 mL	9.7555 mL
20 mM	0.0976 mL	0.4878 mL	0.9756 mL	4.8778 mL
50 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9511 mL
100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.9756 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc