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MC180295

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Purity:98%

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COA HNMR

MC180295

Catalog No. T5533Cas No. 2237942-08-2

MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.

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Pack Size	Price	Availability
1 mg	$85	In Stock
2 mg	$123	In Stock
5 mg	$222	In Stock
10 mg	$329	In Stock
25 mg	$559	In Stock
50 mg	$786	In Stock
100 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$243	In Stock

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Product Introduction

Bioactivity

Description	MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs.
In vitro	MC180295 is a potent, selective CDK9-Cyclin T1 inhibitor with an IC50 of 5 nM, displaying at least 22-fold selectivity over other CDKs, including CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), and CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro.
In vivo	MC180295 (20 mg/kg, i.p., qod) demonstrates significant anti-tumor activity in mice with SW48 cells without inhibiting human T cell growth in vivo.
Alias	(rel)-MC180295

Chemical Properties

Molecular Weight	358.41
Formula	C17H18N4O3S
Cas No.	2237942-08-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 70 mg/mL (195.31 mM )

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7901 mL	13.9505 mL	27.9010 mL	139.5050 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL	27.9010 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL	13.9505 mL
20 mM	0.1395 mL	0.6975 mL	1.3951 mL	6.9753 mL
50 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7901 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc