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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $85 | In Stock | |
2 mg | $123 | In Stock | |
5 mg | $222 | In Stock | |
10 mg | $329 | In Stock | |
25 mg | $559 | In Stock | |
50 mg | $786 | In Stock | |
100 mg | $1,120 | In Stock | |
1 mL x 10 mM (in DMSO) | $243 | In Stock |
Description | MC180295 ((rel)-MC180295) is a novel, potent, and highly selective CDK9 inhibitor with an IC50 of 5 nM, demonstrating over 22-fold selectivity compared to other CDKs. |
In vitro | MC180295 is a potent, selective CDK9-Cyclin T1 inhibitor with an IC50 of 5 nM, displaying at least 22-fold selectivity over other CDKs, including CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), and CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro. |
In vivo | MC180295 (20 mg/kg, i.p., qod) demonstrates significant anti-tumor activity in mice with SW48 cells without inhibiting human T cell growth in vivo. |
Alias | (rel)-MC180295 |
Molecular Weight | 358.41 |
Formula | C17H18N4O3S |
Cas No. | 2237942-08-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 70 mg/mL (195.31 mM ) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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