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MI-538

Catalog No. T16072   CAS 1857417-10-7

MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).

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MI-538 Chemical Structure
MI-538, CAS 1857417-10-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 237.00
10 mg In stock $ 417.00
25 mg In stock $ 697.00
50 mg In stock $ 992.00
100 mg In stock $ 1,330.00
1 mL * 10 mM (in DMSO) In stock $ 296.00
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Purity: 100%
Purity: 99.31%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
Targets&IC50 menin and MLL interaction:21 nM , menin:6.5 nM(Kd)
In vitro Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression.
In vivo Treatment with MI-538 results in a pronounced, about 80%, reduction in the MV4;11 tumor volume, without causing substantial signs of toxicity reflected by less than 10% reduction of the body weight.
Molecular Weight 566.6
Formula C27H25F3N8OS
CAS No. 1857417-10-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (167.67 mM), sonification is recommended.

TargetMolReferences and Literature

1. Borkin D, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913.

Related compound libraries

This product is contained In the following compound libraries:
Histone Modification Compound Library PPI Inhibitor Library Bioactive Compound Library Inhibitor Library Methylation Compound Library Covalent Inhibitor Library Reprogramming Compound Library Chromatin Modification Compound Library Epigenetics Compound Library Bioactive Compounds Library Max

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Keywords

MI-538 1857417-10-7 Chromatin/Epigenetic Epigenetic Reader Domain Histone Methyltransferase inhibit Inhibitor MI538 MI 538 inhibitor

 

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