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MLS000532223

Catalog No. T8473 CAS 16616-39-0

Synonyms: GTPases, Inhibitor, MLS-000532223, MLS 000532223, MLS000532223, Rab, cytoskeleton, actin, Rho GTPases, Ras, inhibit

MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MLS000532223, CAS 16616-39-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
Targets&IC50	Rho family GTPases:16-120 μM(EC50)
In vitro	MLS000532223, a general inhibitor that prevents GTP binding to several GTPases in a dose-dependent manner and is active in biochemical and cell-based secondary assays.?Live-cell imaging and confocal microscopy studies revealed the inhibitor-induced actin reorganization and cell morphology changes, characteristic of Rho GTPases inhibition.

Synonyms	GTPases, Inhibitor, MLS-000532223, MLS 000532223, MLS000532223, Rab, cytoskeleton, actin, Rho GTPases, Ras, inhibit
Molecular Weight	251.241
Formula	C15H9NO3
CAS No.	16616-39-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45mg/ml (179.11 Mm), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15(1):10-20.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Covalent Inhibitor Library Kinase Inhibitor Library Bioactive Compound Library

Related Products

Related compounds with same targets

Compound 3344 AMG-510 racemate MC 976 PROTAC K-Ras Degrader-1 KRas G12C inhibitor 3 KRas G12C inhibitor 1 KRAS inhibitor-8 KRAS G12C inhibitor 17

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.