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MS-PPOH

Catalog No. T41291Cas No. 206052-02-0

MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 µM, respectively.

MS-PPOH

MS-PPOH

Purity: 98.42%
Catalog No. T41291Cas No. 206052-02-0
MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 µM, respectively.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$85In Stock
25 mg$159In Stock
50 mgInquiryIn Stock
100 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Purity:98.42%
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Product Introduction

Bioactivity
Description
MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 µM, respectively.
In vitro
MS-PPOH inhibits cellular EET synthesis, tonic (basal) cell invasion, and migration, and reduces the 11,12-EET (1.0 μM)-induced cell motility [1].
In vivo
Intravenous administration of MS-PPOH (20 mg/kg/day) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on a 2% NaCl drinking solution [3].
Chemical Properties
Molecular Weight323.41
FormulaC16H21NO4S
Cas No.206052-02-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/mL (200.98 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0921 mL15.4603 mL30.9205 mL154.6025 mL
5 mM0.6184 mL3.0921 mL6.1841 mL30.9205 mL
10 mM0.3092 mL1.5460 mL3.0921 mL15.4603 mL
20 mM0.1546 mL0.7730 mL1.5460 mL7.7301 mL
50 mM0.0618 mL0.3092 mL0.6184 mL3.0921 mL
100 mM0.0309 mL0.1546 mL0.3092 mL1.5460 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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