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MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 µM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $47 | In Stock | |
10 mg | $85 | In Stock | |
25 mg | $159 | In Stock | |
50 mg | Inquiry | In Stock | |
100 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase, specifically inhibiting CYP2C8 and CYP2C9 with IC50 values of 15 and 11 µM, respectively. |
In vitro | MS-PPOH inhibits cellular EET synthesis, tonic (basal) cell invasion, and migration, and reduces the 11,12-EET (1.0 μM)-induced cell motility [1]. |
In vivo | Intravenous administration of MS-PPOH (20 mg/kg/day) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on a 2% NaCl drinking solution [3]. |
Molecular Weight | 323.41 |
Formula | C16H21NO4S |
Cas No. | 206052-02-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/mL (200.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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