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Melatonin

Catalog No. T1659   CAS 73-31-4
Synonyms: Melatonine, N-Acetyl-5-methoxytryptamine

Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

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Melatonin Chemical Structure
Melatonin, CAS 73-31-4
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Purity: 99.79%
Purity: 99.78%
Purity: 98.71%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
In vivo Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals[5]. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ1-42[2]. Melatonin treatment and lack of NLRP3-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice[6].
Synonyms Melatonine, N-Acetyl-5-methoxytryptamine
Molecular Weight 232.28
Formula C13H16N2O2
CAS No. 73-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.6 mg/mL (50 mM)

TargetMolReferences and Literature

1. Reiter RJ, et al. J Biomed Sci, 2000, 7(6), 444-458. 2. Reiter RJ, et al. Prog Neurobiol, 1998, 56(3), 359-384. 3. Reiter RJ, et al. Cell Biochem Biophys, 2001, 34(2), 237-256. 4. Vanecek J, et al. Physiol Rev, 1998, 78(3), 687-721. 5. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665. 6. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 7. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 8. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

TargetMolCitations

1. Chen J, Zhang L G, Du H X, et al. Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1‐dependent inhibition of the NLRP3 inflammasome in an EAP mouse model. The Prostate. 2021 2. Xue K H, Jiang Y F, Bai J Y, et al.Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect.Redox Report.2023, 28(1): 2251234.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Human Endogenous Metabolite Library Anti-Cancer Clinical Compound Library Neuronal Signaling Compound Library Autophagy Compound Library Orally Active Compound Library Metabolism Compound Library

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Keywords

Melatonin 73-31-4 Apoptosis Autophagy Endocrinology/Hormones GPCR/G Protein Metabolism Neuroscience Glutathione Peroxidase Endogenous Metabolite ROR Mitophagy CaMK Melatonin Receptor Estrogen/progestogen Receptor inhibit Mitochondrial Autophagy Melatonine Inhibitor N-Acetyl-5-methoxytryptamine inhibitor

 

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