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Methyllycaconitine citrate

Catalog No. T12017Cas No. 351344-10-0
Alias MLA

Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.

Methyllycaconitine citrate

Methyllycaconitine citrate

Purity: 98.69%
Catalog No. T12017Alias MLACas No. 351344-10-0
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
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5 mg$149In Stock
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Purity:98.69%
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Product Introduction

Bioactivity
Description
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
In vitro
Pretreatment with 5 and 10 µM Methyllycaconitine citrate inhibited the decreased cell viability induced by Aβ25–35, which suggested that Methyllycaconitine citrate had a protective effect against Aβ-induced cytotoxicity. Furthermore, cell viability did not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 uM), which suggests a good safety profile[1].
In vivo
The effect of MLA on acute METH-induced effects and neurotoxicity in mice was tested using an in vivo model. The results indicate that MLA (6 mg/kg) inhibited 50% of the METH-induced climbing behavior[2].
AliasMLA
Chemical Properties
Molecular Weight874.92
FormulaC43H58N2O17
Cas No.351344-10-0
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (114.30 mM), Sonication is recommended.
H2O: 1 mg/mL (1.14 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.1430 mL5.7148 mL11.4296 mL57.1481 mL
DMSO
1mg5mg10mg50mg
5 mM0.2286 mL1.1430 mL2.2859 mL11.4296 mL
10 mM0.1143 mL0.5715 mL1.1430 mL5.7148 mL
20 mM0.0571 mL0.2857 mL0.5715 mL2.8574 mL
50 mM0.0229 mL0.1143 mL0.2286 mL1.1430 mL
100 mM0.0114 mL0.0571 mL0.1143 mL0.5715 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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