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Methyllycaconitine citrate

Catalog No. T12017 CAS 351344-10-0

Synonyms: MLA

Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.

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Methyllycaconitine citrate Chemical Structure

Methyllycaconitine citrate, CAS 351344-10-0

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 40.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
In vitro	Pretreatment with 5 and 10 µM Methyllycaconitine citrate inhibited the decreased cell viability induced by Aβ25–35, which suggested that Methyllycaconitine citrate had a protective effect against Aβ-induced cytotoxicity. Furthermore, cell viability did not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 uM), which suggests a good safety profile[1].
In vivo	The effect of MLA on acute METH-induced effects and neurotoxicity in mice was tested using an in vivo model. The results indicate that MLA (6 mg/kg) inhibited 50% of the METH-induced climbing behavior[2].

Synonyms	MLA
Molecular Weight	874.92
Formula	C43H58N2O17
CAS No.	351344-10-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (114.30 mM), Sonification is recommended.

H2O: 1 mg/mL (1.14 mM), Sonification is recommended.

References and Literature

1. Zheng X, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One. 2014 Oct 31;9(10):e111536. 2. Escubedo E, et al. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther. 2005 Nov;315(2):658-67. 3. Lockman PR, et al. Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. J Neurochem. 2005 Jul;94(1):37-44.

Citations

1. Su J C, Pan Q, Xu X, et al. Structurally diverse steroids from an endophyte of Aspergillus tennesseensis 1022LEF attenuates LPS-induced inflammatory response through the cholinergic anti-inflammatory pathway. Chemico-Biological Interactions. 2022: 109998

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Methyllycaconitine citrate 351344-10-0 Neuroscience AChR MLA inhibitor inhibit

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