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NEO2734

Catalog No. T8658Cas No. 2081072-29-7
Alias EP31670

NEO2734 (EP31670) is an orally active, selective inhibitor of p300/CBP and BET bromodomains, with an IC50 of less than 30 nM for both targets.

NEO2734

NEO2734

Purity: 100%
Catalog No. T8658Alias EP31670Cas No. 2081072-29-7
NEO2734 (EP31670) is an orally active, selective inhibitor of p300/CBP and BET bromodomains, with an IC50 of less than 30 nM for both targets.
Pack SizePriceAvailabilityQuantity
1 mg$116In Stock
5 mg$289In Stock
10 mg$478In Stock
25 mg$789In Stock
50 mg$1,080In Stock
100 mg$1,480In Stock
500 mg$2,970In Stock
1 mL x 10 mM (in DMSO)$318In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
NEO2734 (EP31670) is an orally active, selective inhibitor of p300/CBP and BET bromodomains, with an IC50 of less than 30 nM for both targets.
In vitro
NEO2734, a novel dual inhibitor of BET and CBP/p300, is active in both hotspot mutant (F133V) and non-hotspot mutant (Q165P) PCa cells in vitro and in vivo[1].
AliasEP31670
Chemical Properties
Molecular Weight435.44
FormulaC22H24F3N3O3
Cas No.2081072-29-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (63.15 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2965 mL11.4826 mL22.9653 mL114.8264 mL
5 mM0.4593 mL2.2965 mL4.5931 mL22.9653 mL
10 mM0.2297 mL1.1483 mL2.2965 mL11.4826 mL
20 mM0.1148 mL0.5741 mL1.1483 mL5.7413 mL
50 mM0.0459 mL0.2297 mL0.4593 mL2.2965 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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