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NM107

Catalog No. T7215 CAS 20724-73-6

Synonyms: NM-107, 2'-C-Methylcytidine

NM107 (2'-C-Methylcytidine) is a ribonucleoside with broad-spectrum antiviral activity, is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, NM 107 in the wild-type replicon cells with the EC50 of 1.85 μM

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NM107, CAS 20724-73-6

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 57.00
10 mg	In stock	$ 77.00
25 mg	In stock	$ 119.00
50 mg	In stock	$ 157.00
100 mg	In stock	$ 196.00
1 mL * 10 mM (in DMSO)	In stock	$ 62.00

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	NM107 (2'-C-Methylcytidine) is a ribonucleoside with broad-spectrum antiviral activity, is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, NM 107 in the wild-type replicon cells with the EC50 of 1.85 μM
In vitro	NM107 reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. NM107 inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human corona virus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM)[1].
In vivo	Prolonged norovirus shedding may occur in certain patients, such as organ transplant recipients. Established a mouse model for persistent norovirus infection (using the mouse norovirus MNV.CR6 strain). The nucleoside viral polymerase inhibitor 2′-C-methylcytidine (2CMC), but not favipiravir (T-705), reduced viral shedding to undetectable levels. Viral rebound was observed after stopping treatment, which was again effectively controlled by treatment with 2CMC. No drug-resistant variants emerged[2].
Animal Research	For all experiments, age- and sex-matched mice 8 to 12 weeks of age were infected by oral gavage with 10^6 CCID50 (50% cell culture infective doses) of CR6. At 7 days postinfection (p.i.), mice were left untreated (n = 9) or were treated with 100 mg/kg daily of 2'-C-Methylcytidine(2CMC) subcutaneously for 5 (n = 4), 7 (n = 4), or 11 (n = 4) days. Two more rounds of a 14-day treatment (with an ～4-week interval in between) with 2CMC (n = 10) or favipiravir (200 mg/kg daily by oral gavage [n = 5]) were given. On each day after infection, the general condition and weight of treated and untreated mice were assessed, individual stool samples were collected (whenever possible during one daily period of observation), and levels of MNV RNA were quantified by reverse transcriptase quantitative PCR (RT-qPCR)[2].

Synonyms	NM-107, 2'-C-Methylcytidine
Molecular Weight	257.24
Formula	C10H15N3O5
CAS No.	20724-73-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (194.37 mM)

References and Literature

1. Goris N , De Palma A , Toussaint, JeanFrançois, et al. 2'-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus[J]. Antiviral Research, 2007, 73(3):161-168. 2. Rochapereira J , Dycke J V , Neyts J . Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants[J]. Antimicrobial Agents & Chemotherapy, 2015, 60(3):AAC.02198-15. 3. Guedj J , Dahari H , Rong L , et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life[J]. Proceedings of the National Academy of Sciences, 2013, 110(10):3991-3996.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Infection Compound Library Anti-COVID-19 Compound Library Nucleotide Compound Library Anti-Viral Compound Library ReFRAME Related Library Human Metabolite Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

NM107 20724-73-6 Microbiology/Virology Proteases/Proteasome HCV Protease inhibit NM-107 Inhibitor HCV NM 107 2'-C-Methylcytidine Hepatitis C virus inhibitor

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