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NP-313
Catalog No. T24542Cas No. 5397-78-4
Alias NSC-4264, NSC4264, NSC 4264, NP 313
NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.
NP-313
Catalog No. T24542Alias NSC-4264, NSC4264, NSC 4264, NP 313Cas No. 5397-78-4
NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $397 | In Stock | |
| 50 mg | $589 | In Stock | |
| 100 mg | $843 | In Stock | |
| 500 mg | $1,730 | In Stock |
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Purity:98.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. |
| Targets&IC50 | TXA2:3.9 µM, COX-1:1.5 µM |
| In vitro | NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner, reducing thrombin- and A23187-induced aggregation by up to 80% and 60%, respectively.[1] At concentrations of 0-8 μM, NP-313 concentration-dependently inhibits P-selectin expression and collagen- or thrombin-induced thromboxane B2 (TXB2) production in human platelets, and inhibits COX-1 and TXA2 synthase with IC50 values of 1.5 and 3.9 μM, respectively.[1] |
| In vivo | NP-313 (4-16 µg/g; i.v.) significantly prolongs time-to-occlusion (TTO), prolongs bleeding time, and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice.[1] |
| Alias | NSC-4264, NSC4264, NSC 4264, NP 313 |
| Molecular Weight | 249.65 |
| Formula | C12H8ClNO3 |
| Cas No. | 5397-78-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (240.34 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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