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Necrosulfonamide

Catalog No. T7129 CAS 432531-71-0

Synonyms: N-[4-[[(3-甲氧基吡嗪基)氨基]磺酰基]苯基]-3-(5-硝基-2-噻吩基)-2-丙烯酰胺

Necrosulfonamide is a novel inhibitor of MLKL.

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Necrosulfonamide, CAS 432531-71-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Necrosulfonamide is a novel inhibitor of MLKL.
In vivo	Necrosulfonamide attenuates the spinal cord injury via necroptosis inhibition[1]
Animal Research	Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and other major organs. Necroptosis-related factors-RIP1, RIP3, and MLKL-were detected using Western blot. Detections on mitochondrial functions such as adenosine triphosphate generation and activities of superoxide dismutase and caspase-3 were also performed. Finally, ethologic performance was detected using a 21-point open-field locomotion test[1].

Synonyms	N-[4-[[(3-甲氧基吡嗪基)氨基]磺酰基]苯基]-3-(5-硝基-2-噻吩基)-2-丙烯酰胺
Molecular Weight	461.47
Formula	C18H15N5O6S2
CAS No.	432531-71-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang Y , Wang J , Wang H , et al. Necrosulfonamide Attenuates the Spinal Cord Injury Via Necroptosis Inhibition[J]. World Neurosurgery, 2018:S1878875018306569. 2. Menacher G , Balszuweit F , Lang S , et al. Necrosulfonamide – Unexpected effect in the course of a sulfur mustard intoxication[J]. Chemico-Biological Interactions, 2018. 3. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells[J]. Molecular Neurobiology. 2020, 57(11): 4628-4641.

Citations

1. Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 2. Yi Y, Gao K, Zhang L, et al. Zearalenone Induces MLKL-Dependent Necroptosis in Goat Endometrial Stromal Cells via the Calcium Overload/ROS Pathway. International Journal of Molecular Sciences. 2022, 23(17): 10170. 3. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells. Molecular Neurobiology. 2020, 57(11): 4628-4641. 4. Yi Y, Gao K, Lin P, et al. Staphylococcus aureus-Induced Necroptosis Promotes Mitochondrial Damage in Goat Endometrial Epithelial Cells. Animals. 2022, 12(17): 2218.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library MAPK Inhibitor Library

Related Products

Related compounds with same targets

Necrosulfonamide Necrosulfonamide Cerdulatinib hydrochloride URMC-099 PRT062607 hydrochloride IM-54 LY-364947 AZ7550 Mesylate (1421373-99-0 free base)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Necrosulfonamide 432531-71-0 MAPK信号通路 MLK Inhibitor inhibitor inhibit

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