Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 71.00 | |
25 mg | In stock | $ 120.00 | |
50 mg | In stock | $ 205.00 | |
100 mg | In stock | $ 308.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 68.00 |
Description | (E/Z)-Necrosulfonamide is a novel inhibitor of MLKL. |
In vivo | Necrosulfonamide attenuates the spinal cord injury via necroptosis inhibition[1] |
Animal Research | Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and other major organs. Necroptosis-related factors-RIP1, RIP3, and MLKL-were detected using Western blot. Detections on mitochondrial functions such as adenosine triphosphate generation and activities of superoxide dismutase and caspase-3 were also performed. Finally, ethologic performance was detected using a 21-point open-field locomotion test[1]. |
Molecular Weight | 461.47 |
Formula | C18H15N5O6S2 |
CAS No. | 432531-71-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (54.17 mM)
You can also refer to dose conversion for different animals. More
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(E/Z)-Necrosulfonamide 432531-71-0 MAPK MLK Necrosulfonamide inhibitor inhibit