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Nilotinib monohydrochloride monohydrate

Catalog No. T2147 CAS 923288-90-8

Synonyms: Nilotinib (monohydrochloride monohydrate), AMN107 (monohydrochloride monohydrate)

Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosine kinase inhibitor (TKI), and is active against many BCR-ABL mutants.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Nilotinib monohydrochloride monohydrate Chemical Structure

Nilotinib monohydrochloride monohydrate, CAS 923288-90-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 33.00
100 mg	In stock	$ 47.00
200 mg	In stock	$ 59.00
500 mg	In stock	$ 117.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.7%

Biological Description

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Storage & Solubility Information

Description	Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosine kinase inhibitor (TKI), and is active against many BCR-ABL mutants.
In vivo	In the indomethacin-induced enterocolitis rat model, nilotinib has a positive effect on the macroscopic and microscopic pathologic scores, ensuring considerable mucosal healing.?Nilotinib decreases PDGFR α and β levels and increases the colonic apoptotic scores[2].

Synonyms	Nilotinib (monohydrochloride monohydrate), AMN107 (monohydrochloride monohydrate)
Molecular Weight	583.99
Formula	C28H22F3N7O.HCl.H2O
CAS No.	923288-90-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (56.51 mM)

References and Literature

1. Sako H , Fukuda K , Saikawa Y , et al. Antitumor Effect of the Tyrosine Kinase Inhibitor Nilotinib on Gastrointestinal Stromal Tumor (GIST) and Imatinib-Resistant GIST Cells[J]. PLOS ONE, 2014, 9(9):e107613. 2. Gozde Dervis Hakim Mujde Soyturk Mehtat Unlu Pinar Ataca Meral Karaman Ozgul Sagol Elif Borekci Osman Yilmaz. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis:A rat model[J]. 2015.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Kinase Inhibitor Library EMA Approved Drug Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Approved Drug Library FDA-Approved Kinase Inhibitor Library

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Related compounds with same targets

AST 487 Agerafenib SGX-523 Gypsogenin GMB-475 Lyn-IN-1 Multi-kinase inhibitor 1 Masitinib

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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