Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 44.00 | |
10 mg | In stock | $ 73.00 | |
25 mg | In stock | $ 147.00 | |
50 mg | In stock | $ 229.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. |
Targets&IC50 | Folate cofactor:11 nM (Ki) |
Synonyms | Thymitaq, AG 337 |
Molecular Weight | 357.26 |
Formula | C14H14Cl2N4OS |
CAS No. | 152946-68-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: >10 mM
You can also refer to dose conversion for different animals. More
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Nolatrexed dihydrochloride 152946-68-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis AG337 Nolatrexed Inhibitor Thymidylate Synthase inhibit AG-337 Nolatrexed Dihydrochloride Thymitaq AG 337 inhibitor