Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
Description | Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. |
Targets&IC50 | folate cofactor:11 nM (Ki) |
Synonyms | 盐酸诺拉曲塞, AG 337, Thymitaq |
Molecular Weight | 357.25 |
Formula | C14H14Cl2N4OS |
CAS No. | 152946-68-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: >10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Nolatrexed dihydrochloride 152946-68-4 DNA损伤和修复 细胞周期 DNA/RNA Synthesis AG-337 Nolatrexed Inhibitor Thymidylate Synthase inhibit Thymitaq AG 337 AG337 inhibitor