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Nolatrexed dihydrochloride

Catalog No. T2627 CAS 152946-68-4

Synonyms: 盐酸诺拉曲塞, AG 337, Thymitaq

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

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Nolatrexed dihydrochloride, CAS 152946-68-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

folate cofactor:11 nM (Ki)

Synonyms	盐酸诺拉曲塞, AG 337, Thymitaq
Molecular Weight	357.25
Formula	C14H14Cl2N4OS
CAS No.	152946-68-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: >10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hughes AN, et al. Br J Y. 2000 May;82(9):1519-27.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nolatrexed dihydrochloride 152946-68-4 DNA损伤和修复细胞周期 DNA/RNA Synthesis AG-337 Nolatrexed Inhibitor Thymidylate Synthase inhibit Thymitaq AG 337 AG337 inhibitor

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