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Omarigliptin

Catalog No. T2316 CAS 1226781-44-7

Synonyms: MK-3102

Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.

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Omarigliptin, CAS 1226781-44-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 223.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 531.00
500 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 140.00

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Purity: 100%

Purity: 99.70%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.
Targets&IC50	DPP4:1.6 nM

Synonyms	MK-3102
Molecular Weight	398.43
Formula	C17H20F2N4O3S
CAS No.	1226781-44-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (125.49 mM)

References and Literature

1. Biftu T, et al. J Med Chem. 2014 Apr 24;57(8):3205-12. 2. Du H, Wang S. Omarigliptin Mitigates Lipopolysaccharide-Induced Neuroinflammation and Dysfunction of the Integrity of the Blood–Brain Barrier[J]. ACS Chemical Neuroscience. 2020

Citations

1. Du H, Wang S Omarigliptin Mitigates Lipopolysaccharide-Induced Neuroinflammation and Dysfunction of the Integrity of the Blood–Brain Barrier. ACS Chemical Neuroscience. 2020 2. Heo R, Kang M, Mun S Y, et al. Antidiabetic Omarigliptin Dilates Rabbit Aorta by Activating Kv Channels and the SERCA Pump. Fundamental & Clinical Pharmacology. 2022 3. Heo R, Kang M, Mun S Y, et al.Antidiabetic omarigliptin dilates rabbit aorta by activating voltage‐dependent K+ channels and the sarco/endoplasmic reticulum Ca2+‐ATPase pump.Fundamental & Clinical Pharmacology.2023, 37(1): 75-84.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Highly Selective Inhibitor Library Human Metabolite Library ReFRAME Related Library Target-Focused Phenotypic Screening Library Anti-Aging Compound Library Bioactive Compound Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

Proteasome-IN-1 Baceridin Lactacystin Alogliptin Benzoate PSI Vildagliptin Z-LLF-CHO DBPR108

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Omarigliptin 1226781-44-7 Proteases/Proteasome Ubiquitination DPP-4 Proteasome MK-3102 inhibit glucagon like peptide-1 anti-parkinsonian Dipeptidyl Peptidase blood-brain barrier MK 3102 DPP orally active Inhibitor MK3102 anti-diabetic inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.