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PD-161570

Catalog No. T23127   CAS 192705-80-9
Synonyms: Inhibitor, Fibroblast growth factor receptor, HER1, kinases, PD 161570, autophosphorylation, PDGFR, PD161570, FGFR, Src, inhibit, TGF-β Receptor, ATP-competitive, Epidermal growth factor receptor, tyrosine, Platelet-derived growth factor receptor, disease, EGFR, anti-cancer, angiogenesis, ErbB-1, FGFR1, Transforming growth factor beta receptors, cardiovascular, anti-proliferation, PD-161570

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.

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PD-161570, CAS 192705-80-9
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
Targets&IC50 FGFR1 autophosphorylation:622 nM, FGFR1:39.9 nM (IC50), FGFR1:42 nM (Ki)
Synonyms Inhibitor, Fibroblast growth factor receptor, HER1, kinases, PD 161570, autophosphorylation, PDGFR, PD161570, FGFR, Src, inhibit, TGF-β Receptor, ATP-competitive, Epidermal growth factor receptor, tyrosine, Platelet-derived growth factor receptor, disease, EGFR, anti-cancer, angiogenesis, ErbB-1, FGFR1, Transforming growth factor beta receptors, cardiovascular, anti-proliferation, PD-161570
Molecular Weight 532.51
Formula C26H35Cl2N7O
CAS No. 192705-80-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/ml (56.34 mM), Need ultrasonic

Ethanol: <53.25mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Hamby JM, et al. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem. 1997 Jul 18;40(15):2296-303.

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