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PD-161570

Catalog No. T23127 CAS 192705-80-9

Synonyms: Inhibitor, Fibroblast growth factor receptor, HER1, kinases, PD 161570, autophosphorylation, PDGFR, PD161570, FGFR, Src, inhibit, TGF-β Receptor, ATP-competitive, Epidermal growth factor receptor, tyrosine, Platelet-derived growth factor receptor, disease, EGFR, anti-cancer, angiogenesis, ErbB-1, FGFR1, Transforming growth factor beta receptors, cardiovascular, anti-proliferation, PD-161570

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.

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PD-161570, CAS 192705-80-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
Targets&IC50	FGFR1 autophosphorylation:622 nM, FGFR1:39.9 nM (IC50), FGFR1:42 nM (Ki)

Synonyms	Inhibitor, Fibroblast growth factor receptor, HER1, kinases, PD 161570, autophosphorylation, PDGFR, PD161570, FGFR, Src, inhibit, TGF-β Receptor, ATP-competitive, Epidermal growth factor receptor, tyrosine, Platelet-derived growth factor receptor, disease, EGFR, anti-cancer, angiogenesis, ErbB-1, FGFR1, Transforming growth factor beta receptors, cardiovascular, anti-proliferation, PD-161570
Molecular Weight	532.51
Formula	C26H35Cl2N7O
CAS No.	192705-80-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/ml (56.34 mM), Need ultrasonic

Ethanol: <53.25mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Hamby JM, et al. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem. 1997 Jul 18;40(15):2296-303.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.