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PKG Substrate acetate（81187-14-6 free base)

Catalog No. TP1787L CAS TP1787L

PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).

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PKG Substrate acetate（81187-14-6 free base) Chemical Structure

PKG Substrate acetate（81187-14-6 free base), CAS TP1787L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 101.00
5 mg	In stock	$ 367.00
10 mg	In stock	$ 549.00
25 mg	In stock	$ 886.00
50 mg	In stock	$ 1,190.00
100 mg	In stock	$ 1,630.00

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Purity: 99.30%

Biological Description

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Description

In vitro

Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG[1].

Molecular Weight	962.08
Formula	C37H71N17O13
CAS No.	TP1787L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wong A, et al. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287(43):36051-8.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Peptide Compound Library Kinase Inhibitor Library NO PAINS Compound Library Anti-Obesity Compound Library

Related Products

Related compounds with same targets

AT7867 MLN8054 GSK180736A A-443654 H-89 dihydrochloride CREBtide acetate(149155-45-3 free base) A-674563 HCl (552325-73-2(free base)) PKItide

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Keywords

PKG Substrate acetate（81187-14-6 free base) TP1787L Tyrosine Kinase/Adaptors PKA 81187-14-6 81187-14-6 free base PKG Substrate acetate（81187 14 6 free base) PKG Substrate Acetate PKG Substrate acetate（81187146 free base) inhibitor inhibit

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