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PKG Substrate acetate（81187-14-6 free base)

Catalog No. TP1787L CAS TP1787L

PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).

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PKG Substrate acetate（81187-14-6 free base), CAS TP1787L

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Purity: 98%

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Description

In vitro

Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG[1].

Molecular Weight	962.08
Formula	C37H71N17O13
CAS No.	TP1787L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wong A, et al. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287(43):36051-8.

Related compound libraries

This product is contained In the following compound libraries：

Stem Cell Differentiation Compound Library

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Keywords

PKG Substrate acetate（81187-14-6 free base) TP1787L 蛋白酪氨酸激酶 PKA PKG Substrate acetate（81187 14 6 free base) PKG Substrate acetate（81187146 free base) Inhibitor inhibitor inhibit

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