Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 143.00 | |
10 mg | In stock | $ 212.00 | |
25 mg | In stock | $ 358.00 | |
50 mg | In stock | $ 528.00 | |
100 mg | In stock | $ 756.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 167.00 |
Description | Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp. |
In vitro | The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function[1] |
Source |
Molecular Weight | 418.52 |
Formula | C24H34O6 |
CAS No. | 10351-88-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (131.42 mM)
You can also refer to dose conversion for different animals. More
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Phyllanthin 10351-88-9 NF-Κb NF-κB hepatoprotective inhibit bioactive antioxidative Phyllanthus Inhibitor amarus lignan inhibitor