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Piclozotan

Catalog No. T28414Cas No. 182415-09-4
Alias SUNN-4057, SUN-N-4057, SUNN4057, SUN-4057, SUN4057

Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advanced Parkinson's disease.

Piclozotan

Piclozotan

Purity: 99%
Catalog No. T28414Alias SUNN-4057, SUN-N-4057, SUNN4057, SUN-4057, SUN4057Cas No. 182415-09-4
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advanced Parkinson's disease.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Purity:99%
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Product Introduction

Bioactivity
Description
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advanced Parkinson's disease.
In vivo
Piclozotan (SUN N4057) (0.018 and 0.036 mg/kg/h; continuous subcutaneous infusion; 3 to 4 weeks; Parkinsonian rats) significantly lengthened the duration of rotational behavior by 26% and attenuated the increase in striatal levodopa-derived extracellular dopamine levels compared with the control group. Piclozotan (0.018 and 0.036 mg/kg/h, plasma concentrations 5.3±0.7 and 14.3±2.9 ng/ml) reduced levodopa-induced forelimb hyperkinesia by 55% and 69%, respectively, at 1h relative to the control.[1]
AliasSUNN-4057, SUN-N-4057, SUNN4057, SUN-4057, SUN4057
Chemical Properties
Molecular Weight409.91
FormulaC23H24ClN3O2
Cas No.182415-09-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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