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Protirelin

Catalog No. T6956 CAS 24305-27-9

Synonyms: Lopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, TRF

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Protirelin, CAS 24305-27-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 65.00
25 mg	In stock	$ 135.00
50 mg	In stock	$ 217.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
Targets&IC50	THR:
In vivo	Protirelin (TRH), a neuropeptide predating the split between protostomes and deuterostomes, has likely played a role in regulating postembryonic growth and reproduction from its evolutionary origins. This study explores Protirelin's impact on body temperature, specifically through the administration of 1, 5, 10, and 20 mg/kg doses intraperitoneally to male Wistar rats (200-250 g). The findings reveal that Protirelin induces a temporary, dose-dependent increase in body temperature. Notably, thyroidectomized rats receiving a 20 mg/kg dose of Protirelin do not exhibit the significant hyperthermia observed in sham-operated counterparts, indicating that thyroid hormone release may be essential to Protirelin's hyperthermic effect.
Animal Research	Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.

Synonyms	Lopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, TRF
Molecular Weight	362.38
Formula	C16H22N6O4
CAS No.	24305-27-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 67 mg/mL (184.9 mM)

DMSO: 67 mg/mL (184.9 mM)

H2O: 66 mg/mL (182.1 mM)

References and Literature

1. Van Sinay E,etal.Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074. 2. Noda Y,etal.Hyperthermia induced by thyrotropin-releasing hormone (TRH, protirelin) in the rat.Kurume Med J. 1979;26(2):107-12.

Related compound libraries

This product is contained In the following compound libraries：

RO5 Drug-like Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Protirelin 24305-27-9 Endocrinology/Hormones Metabolism Endogenous Metabolite Thyroid hormone receptor(THR) THR Lopremone pGlu-His-Pro-NH2 Synthetic thyrotropin-releasing hormone Inhibitor Thyroliberin Thyroid Hormone Receptor TRH inhibit TRF inhibitor

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