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Pyributicarb

Catalog No. T7618 CAS 88678-67-5

Synonyms: TSH-888

Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

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Pyributicarb, CAS 88678-67-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 31.00
25 mg	In stock	$ 48.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 105.00
200 mg	In stock	$ 155.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

In vitro

Pyributicarb was found to increase the CYP3A4 reporter activity at 0.1 to 1 microM more strongly than typical CYP3A4 inducer rifampicin.?Expression of hPXR-siRNA clearly diminished the pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreased the endogenous CYP3A4 mRNA levels in HepG2 cells.?Pyributicarb caused enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1].

Synonyms	TSH-888
Molecular Weight	330.44
Formula	C18H22N2O2S
CAS No.	88678-67-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (302.63 mM)

References and Literature

1. Matsubara T , Noracharttiyapot W , Toriyabe T , et al. Assessment of Human Pregnane X Receptor Involvement in Pesticide-Mediated Activation of CYP3A4 Gene[J]. Drug Metabolism and Disposition, 2007, 35(5):728-733. 2. Kojima H, Sata F, Takeuchi S,et al.Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.Toxicology. 2011 Feb 27;280(3):77-87.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Bioactive Compound Library Metabolism Compound Library Anti-Cancer Compound Library Anti-Aging Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library

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Keywords

Pyributicarb 88678-67-5 Metabolism P450 Cytochrome P450 TSH888 CYPs Inhibitor TSH-888 TSH 888 inhibit inhibitor

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