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QX77

Catalog No. T4663   CAS 1798331-92-6

QX77 is a chaperone-mediated autophagy (CMA) activator.

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QX77 Chemical Structure
QX77, CAS 1798331-92-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
5 mg In stock $ 72.00
10 mg In stock $ 122.00
25 mg In stock $ 222.00
50 mg In stock $ 369.00
100 mg In stock $ 549.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 98.38%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description QX77 is a chaperone-mediated autophagy (CMA) activator.
In vitro Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane.
Molecular Weight 300.74
Formula C16H13ClN2O2
CAS No. 1798331-92-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (49.88 mM)

TargetMolReferences and Literature

1. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346

TargetMolCitations

1. Liu C, Sun W, Zhu T, et al. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biology. 2022: 102292.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max Autophagy Compound Library NO PAINS Compound Library

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Keywords

QX77 1798331-92-6 Autophagy Others LAMP2A Inhibitor Rab11 inhibit QX 77 CMA pluripotency MEFs QX-77 inhibitor

 

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