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Quercetin

Catalog No. T2174 CAS 117-39-5

Synonyms: Sophoretin

Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.

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Quercetin, CAS 117-39-5

Pack Size	Availability	Price/USD
500 mg	In stock	$ 42.00
1 g	In stock	$ 50.00
5 g	In stock	$ 79.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 98.05%

Purity: 97.27%

Purity: 96.55%

Purity: 96.29%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
Targets&IC50	PI3Kγ:2.4 μM, PI3Kδ:3.0 μM
In vitro	In xenografts of human prostate cancer LNCaP and PC-3 cells, the combined administration of Quercetin (75 mg/kg) and 2-methoxyestradiol effectively inhibits tumor growth.
In vivo	Quercetin inhibits TNF-induced LDH release, reduces EC-dependent adhesion of neutrophils to bovine pulmonary artery endothelial cells (BPAEC), and also suppresses DNA synthesis and cell proliferation in these cells. As a PI3K inhibitor (IC50=2.4 - 5.4 μM), quercetin strongly inhibits PI3K and Src kinases, moderately inhibits Akt1/2, and has a slight effect on PKC, p38, and ERK1/2.
Source	Natural Products > Fagaceae > Quercus

Synonyms	Sophoretin
Molecular Weight	302.24
Formula	C15H10O7
CAS No.	117-39-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 4 mg/mL(13.2 mM)

DMSO: 57 mg/mL (188.6 mM)

References and Literature

1. Srivastava S, et al. Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis. Sci Rep. 2016 Apr 12;6:24049. 2. Hashemzaei M, et al. Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo. Oncol Rep. 2017 Aug;38(2):819-828. 3. Lan H, et al. Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells. Cell Physiol Biochem. 2017;43(2):553-567. 4. Liu H, et al. Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice. Obstet Gynecol Sci. 2019 Jul;62(4):242-248. 5. Islam MT, et al. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. Aging Cell. 2023 Feb;22(2):e13767. 6. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020 7. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients. 2020, 12(7): 1927. 8. Peng D, Chen L, Sun Y, et al. Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling[J]. Biomedicine & pharmacotherapy= Biomedecine & pharmacotherapie. 2020, 125: 109984.

Citations

1. Guo C R, Zhang Z Z, Zhou X, et al.Chronic cough relief by allosteric modulation of P2X3 without taste disturbance.Nature Communications.2023, 14(1): 5844. 2. Zhang Z, Shi J, Wu Q, et al.JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia.iScience.2023 3. Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477. 4. Gul H, Ali R, Rauf M, et al.Aspergillus welwitschiae BK Isolate Ameliorates the Physicochemical Characteristics and Mineral Profile of Maize under Salt Stress.Plants.2023, 12(8): 1703. 5. Li S, Hao L, Hu X, et al.A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification.Infectious Agents and Cancer.2023, 18(1): 41. 6. Qadir M, Hussain A, Hamayun M, et al. Phytohormones Producing Acinetobacter bouvetii P1 Mitigates Chromate Stress in Sunflower by Provoking Host Antioxidant Response. Antioxidants. 2021, 10(12): 1868. 7. Peng D, Chen L, Sun Y, et al. Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling. Biomedicine & Pharmacotherapy. 2020, 125: 109984 8. Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477. 9. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135 10. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Biochemical and Biophysical Research Communications. 2020

11. Jang S A, Hwang Y H, Yang H, et al. Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis. Biomedicine & Pharmacotherapy. 2022, 147: 112640. 12. Shim K S, Hwang Y H, Jang S A, et al. Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 1927 13. Zhu L, Liu R, Liu T, et al. A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2019, 164: 520-527 14. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation. Molecules. 2021 Feb 3;26(4):784. 15. Zhang Y, Yu F, Hao J, et al. Study on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice. Frontiers in Veterinary Science. 2021, 8. 16. Lee S J, Yang H, Kim S C, et al.Ethanol Extract of Radix Asteris Suppresses Osteoclast Differentiation and Alleviates Osteoporosis.International Journal of Molecular Sciences.2023, 24(22): 16526. 17. Peng C, Ai Q, Zhao F, et al.Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.European Journal of Pharmacology.2023: 176264. 18. Wang T, Yang C, Li Z, et al.Flavonoid 4, 4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.Redox Biology.2023: 103017.

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Related compound libraries

This product is contained In the following compound libraries：

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Keywords

Quercetin 117-39-5 Apoptosis Autophagy Immunology/Inflammation Metabolism NF-Κb PI3K/Akt/mTOR signaling PI3K Mitophagy Reactive Oxygen Species inhibit Inhibitor Phosphoinositide 3-kinase Mitochondrial Autophagy Sophoretin inhibitor

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