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Relugolix

Catalog No. T3630 CAS 737789-87-6

Synonyms: RVT-601, TAK-385

Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively binds to and blocks the GnRH receptor in the anterior pituitary gland, which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Relugolix, CAS 737789-87-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 209.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 538.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.67%

Purity: 98.85%

Purity: 98.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

TNK2 (D163E mutations):38nM, TNK2 (R806Q mutations):113 nM

Synonyms	RVT-601, TAK-385
Molecular Weight	623.63
Formula	C29H27F2N7O5S
CAS No.	737789-87-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL(88.2 mM)

References and Literature

1. MacLean DB et al. J Clin Endocrinol Metab. 2015 Dec;100(12):4579-87. 2. Nakata D et al. Eur J Pharmacol. 2014 Jan 15;723:167-74.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library ReFRAME Related Library FDA-Approved Drug Library

Related Products

Related compounds with same targets

AG 045572 LHRH (R)-Elagolix Goserelin acetate Linzagolix Deslorelin acetate(57773-65-6 free base) Degarelix acetate(214766-78-6 free base) GnRH-R antagonist 1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Relugolix 737789-87-6 GPCR/G Protein GNRH Receptor inhibit Gonadotropin releasing hormone receptor endometriosis TAK 385 GnRH Receptor GnRH RVT-601 prostate cancer TAK385 GNRHR antagonistic Inhibitor RVT601 uterine fibroid TAK-385 FSH RVT 601 inhibitor

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