Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 47.00 | |
50 mg | In stock | $ 55.00 | |
100 mg | In stock | $ 81.00 | |
200 mg | In stock | $ 108.00 | |
500 mg | In stock | $ 135.00 |
Description | Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease. |
Targets&IC50 | cholinesterase:5.5 μM |
In vivo | Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1]. |
Cell Research | Chronic toxicity is assessed 7 days after continuous exposure of cells to donepezil or rivastigmine using cell viability and cell esterase activity and the estimated cell numbers as parameters for viability. Culture medium including the tested drugs is changed once after 4 days.(Only for Reference) |
Synonyms | SDZ-ENA 713, S-Rivastigmine, Exelon |
Molecular Weight | 250.34 |
Formula | C14H22N2O2 |
CAS No. | 123441-03-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (199.73 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rivastigmine 123441-03-2 Neuroscience AChE parasympathomimetic Parkinson's acetylcholinesteras SDZ-ENA 713 Alzheimer's BBB disease ChE SDZ-ENA713 Cholinesterase (ChE) butyrylcholinesterase orally cholinesterase BChE Inhibitor SDZ-ENA-713 cholinergic inhibit S-Rivastigmine Exelon inhibitor