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Rivastigmine

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Catalog No. T0229Cas No. 123441-03-2
Alias S-Rivastigmine, SDZ-ENA 713, Exelon

Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.

Rivastigmine

Rivastigmine

🥰Excellent
Purity: 99.85%
Catalog No. T0229Alias S-Rivastigmine, SDZ-ENA 713, ExelonCas No. 123441-03-2
Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
Pack SizePriceAvailabilityQuantity
25 mg$47In Stock
50 mg$55In Stock
100 mg$81In Stock
200 mg$108In Stock
500 mg$135In Stock
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Purity:99.85%
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Product Introduction

Bioactivity
Description
Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
Targets&IC50
ChE:5.5 μM
In vivo
Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1].
Cell Research
Chronic toxicity is assessed 7 days after continuous exposure of cells to donepezil or rivastigmine using cell viability and cell esterase activity and the estimated cell numbers as parameters for viability. Culture medium including the tested drugs is changed once after 4 days.(Only for Reference)
AliasS-Rivastigmine, SDZ-ENA 713, Exelon
Chemical Properties
Molecular Weight250.34
FormulaC14H22N2O2
Cas No.123441-03-2
SmilesCCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C
Relative Density.1.038g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 70 mg/mL (279.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9946 mL19.9728 mL39.9457 mL199.7284 mL
5 mM0.7989 mL3.9946 mL7.9891 mL39.9457 mL
10 mM0.3995 mL1.9973 mL3.9946 mL19.9728 mL
20 mM0.1997 mL0.9986 mL1.9973 mL9.9864 mL
50 mM0.0799 mL0.3995 mL0.7989 mL3.9946 mL
100 mM0.0399 mL0.1997 mL0.3995 mL1.9973 mL

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