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Rivastigmine

Catalog No. T0229   CAS 123441-03-2
Synonyms: SDZ-ENA 713, S-Rivastigmine, Exelon

Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.

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Rivastigmine Chemical Structure
Rivastigmine, CAS 123441-03-2
Pack Size Availability Price/USD Quantity
25 mg In stock $ 47.00
50 mg In stock $ 55.00
100 mg In stock $ 81.00
200 mg In stock $ 108.00
500 mg In stock $ 135.00
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Purity: 99.85%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
Targets&IC50 cholinesterase:5.5 μM
In vivo Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1].
Cell Research Chronic toxicity is assessed 7 days after continuous exposure of cells to donepezil or rivastigmine using cell viability and cell esterase activity and the estimated cell numbers as parameters for viability. Culture medium including the tested drugs is changed once after 4 days.(Only for Reference)
Synonyms SDZ-ENA 713, S-Rivastigmine, Exelon
Molecular Weight 250.34
Formula C14H22N2O2
CAS No. 123441-03-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (199.73 mM)

TargetMolReferences and Literature

1. Jann MW, et al. Pharmacotherapy. 2000, 20(1):1-12. 2. Abdel-Aal RA, et al. Eur J Pharmacol. 2011, 659(2-3):169-76. 3. Goldblum D, et al. Ophthalmic Res. 2002, 34(2):97-103.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Clinical Compound Library Drug Repurposing Compound Library Drug-Fragment Library Neurotransmitter Receptor Compound Library Approved Drug Library Human Metabolite Library Inhibitor Library Neuronal Signaling Compound Library Pediatric Drug Library

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Keywords

Rivastigmine 123441-03-2 Neuroscience AChE parasympathomimetic Parkinson's acetylcholinesteras SDZ-ENA 713 Alzheimer's BBB disease ChE SDZ-ENA713 Cholinesterase (ChE) butyrylcholinesterase orally cholinesterase BChE Inhibitor SDZ-ENA-713 cholinergic inhibit S-Rivastigmine Exelon inhibitor

 

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