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S-23

Catalog No. T20789   CAS 1010396-29-8
Synonyms: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide, S23

S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

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S-23 Chemical Structure
S-23, CAS 1010396-29-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 64.00
25 mg In stock $ 128.00
50 mg In stock $ 197.00
100 mg In stock $ 322.00
200 mg In stock $ 478.00
500 mg In stock $ 772.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 98.55%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
Targets&IC50 Androgen Receptor:1.7 nM(Ki)
In vitro Administration of 10 nM S-23 induces AR-mediated transcriptional activation in CV-1 cells [2].
In vivo Administration of S-23 to castrated animals increases the weights of the androgen-dependent organ dose-dependently with the ED50s of S-23 in the prostate and levator ani muscle of 0.43 and 0.079 mg/d, respectively[2].
Synonyms (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide, S23
Molecular Weight 416.75
Formula C18H13ClF4N2O3
CAS No. 1010396-29-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 88 mg/mL (211.16 mM)

TargetMolReferences and Literature

1. Coss CC, Bauler M, Narayanan R, Miller DD, Dalton JT. Alanine aminotransferase regulation by androgens in non-hepatic tissues. Pharm Res. 2012 Apr;29(4):1046-56. 2. Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide:a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):385-395.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Anti-Prostate Cancer Compound Library Bioactive Compound Library Nuclear Receptor Compound Library Orally Active Compound Library Endocrinology-Hormone Compound Library Anti-Cancer Compound Library Transcription Factor-Targeted Compound Library

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Keywords

S-23 1010396-29-8 Endocrinology/Hormones Androgen Receptor activation levator castrated S 23 ani Inhibitor (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide vesicle cells transcriptional muscle prostate S23 seminal CV-1 inhibit inhibitor

 

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