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SB-200646A

SB-200646A
SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts anxiolytic and electrophysiological properties in vivo.
Catalog No. T22423Cas No. 143797-62-0

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SB-200646A

Catalog No. T22423Cas No. 143797-62-0

SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts anxiolytic and electrophysiological properties in vivo.
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Pack SizePriceAvailabilityQuantity
2 mg$355 days
1 mL x 10 mM (in DMSO)$765 days
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Product Introduction

Bioactivity
Description
SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts anxiolytic and electrophysiological properties in vivo.
In vitro
SB200646A (4 μM) eliminates the increase in miniature inhibitory postsynaptic current (mIPSC) frequency induced by ethanol, without affecting the basal mIPSC frequency.
In vivo
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. Intravenous administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and percentage of events as bursts in spontaneously active VTA dopaminergic neurons and increases the percentage of events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].
Chemical Properties
Molecular Weight302.76
FormulaC15H15ClN4O
Cas No.143797-62-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 225 mg/mL (743.2 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3029 mL16.5147 mL33.0295 mL165.1473 mL
5 mM0.6606 mL3.3029 mL6.6059 mL33.0295 mL
10 mM0.3303 mL1.6515 mL3.3029 mL16.5147 mL
20 mM0.1651 mL0.8257 mL1.6515 mL8.2574 mL
50 mM0.0661 mL0.3303 mL0.6606 mL3.3029 mL
100 mM0.0330 mL0.1651 mL0.3303 mL1.6515 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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