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SB-265610

Catalog No. T16850 CAS 211096-49-0

Synonyms: GSK-CXCR2

SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).

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SB-265610, CAS 211096-49-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 396.00
50 mg	In stock	$ 589.00
100 mg	In stock	$ 843.00
500 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 97.67%

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Description	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).
Targets&IC50	CXCR2 (CINC-1-induced calcium mobilization):3.7 nM, CXCR2 (neutrophil chemotaxis):70 nM
In vitro	SB-265610 decreases the antiapoptotic effect of CINC-1 to the levels of those untreated with CINC-1. SB-265610 antagonizes rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization (IC50 of 3.7 nM) and rat neutrophil chemotaxis in a concentration-dependent manner (IC50 of 70 nM) [1].
In vivo	SB-265610 (100 mg/kg/day;p.o; daily; for 5 days; CXCR2 wild type mice) treatment markedly delays healing parameters in CXCR2 wild type mice during the wound repair process[2].

Synonyms	GSK-CXCR2
Molecular Weight	357.16
Formula	C14H9BrN6O
CAS No.	211096-49-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 66 mg/mL (184.79 mM)

References and Literature

1. Auten RL, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5. 2. Milatovic S, et al. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 2003 May-Jun;11(3):213-9. 3. Li Yang, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 2008 Jan;13(1):23-35.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Membrane Protein-targeted Compound Library Covalent Inhibitor Library Cytokine Inhibitor Library ReFRAME Related Library Autophagy Compound Library Immuno-Oncology Compound Library Bioactive Compounds Library Max Chemokine Inhibitor Library

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Related compounds with same targets

Balixafortide Tannic acid CXCR4-IN-1 JMS-17-2 SB225002 TAK-779 Reparixin DOTA-CXCR4-L

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Keywords

SB-265610 211096-49-0 Autophagy GPCR/G Protein Immunology/Inflammation CXCR nonpeptide inhibit Inhibitor inflammation recruitment SB 265610 Delay healing neutrophil wound CXC chemokine receptors GSK-CXCR2 SB265610 inhibitor

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