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SBI-115

Catalog No. T7428 CAS 882366-16-7

SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5

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SBI-115, CAS 882366-16-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 48.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 148.00
50 mg	In stock	$ 232.00
100 mg	In stock	$ 374.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.67%

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Description	SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
In vivo	Stimulation of cholangiocytes with TLCA following by SBI-115 treatment resulted in dose-dependent (by 32–48%) inhibition of cell proliferation.
Cell Research	cAMP was detected by the Bridge-It cAMP designer cAMP assay. Cholangiocytes (10,000/well) were incubated with TLCA, OA, C1 and C2 (all, 25 μM), SBI-115 (100 and 200 μM) and pasireotide (20 μM) for 15–30 min. Doses of drugs were chosen based on published data or dose ranging (SBI-115). Cell proliferation was determined by CellTiter 96 Aqueous One Solution Cell Proliferation Assay ?and by cell counting using the Cellometer Auto4 ?cell counter.?Cholangiocytes (2500 cells/well) were grown for 24–48 hours and then treated with TGR5 agonists (all, 25 μM), SBI-115 (100 and 200 μM) and pasireotide (20 μM) for additional 24 hours.?Alterations in cell proliferation after treatment were expressed as percent change compared to un-treated cholangiocytes in which cell proliferation was considered to be equal 100%.

Molecular Weight	340.78
Formula	C14H13ClN2O4S
CAS No.	882366-16-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (440.17 mM)

References and Literature

1. Masyuk TV, Masyuk AI, Lorenzo Pisarello M,et al.TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling[J].Hepatology. 2017 Oct;66(4):1197-1218.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Cancer Compound Library

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Keywords

SBI-115 882366-16-7 GPCR/G Protein GPCR19 G protein-coupled Bile Acid Receptor 1 TGR5 GPBAR1 Inhibitor G-protein coupled receptor 19 SBI 115 SBI115 inhibit inhibitor

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