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SD-169

Catalog No. T7661 CAS 1670-87-7

Synonyms: SD 169

SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.

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SD-169, CAS 1670-87-7

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 51.00
50 mg	In stock	$ 80.00
100 mg	In stock	$ 122.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.
Targets&IC50	p38α MAPK:3.2 nM (IC50), p38β MAPK:122 nM (IC50)
In vivo	Animals were gavaged with Scios SD-169 (10 or 30 mg/kg) or excipient (PEG300) 1 day before and daily after crush injury to the sciatic nerve.?SD-169 is a proprietary oral inhibitor of p38 MAPK activity.?The rate of axonal regeneration was determined by the functional pinch test and was significantly increased in treated animals 8 days after crush injury (P < 0.05;?30 mg/kg dose).?In SD-169-treated animals with nerve transection, nerve fibers regenerating through a silicone chamber were morphologically more mature than untreated nerves when observed 28 days after transection.?TNF immunofluorescence of distal nerve segments after crush injury suggested that SD-169 reduced SC TNF protein[1].

Synonyms	SD 169
Molecular Weight	160.17
Formula	C9H8N2O
CAS No.	1670-87-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (62.43 mM)

References and Literature

1. Myers R R , Sekiguchi Y , Kikuchi S , et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration[J]. Experimental Neurology, 2003, 184(2):0-614. 2. Klapsing P , Herrmann P , Quintel M , et al. Automatic quantitative computed tomography segmentation and analysis of aerated lung volumes in acute respiratory distress syndrome—A comparative diagnostic study[J]. Journal of Critical Care, 2016, 42:184-191.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Osteogenesis Compound Library Cancer Cell Differentiation Compound Library Kinase Inhibitor Library Orally Active Compound Library Reprogramming Compound Library MAPK Inhibitor Library Anti-Pancreatic Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Colorectal Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SD-169 1670-87-7 MAPK p38 MAPK HSPs p38α kinases SD169 SD 169 protein inhibit Inhibitor heat diabete mitogen-activated proteins shock inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.