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SGN-2FF

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.

Catalog No. T12894Cas No. 2089647-47-0

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Purity:98%

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SGN-2FF

Catalog No. T12894Cas No. 2089647-47-0

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$90	In Stock
5 mg	$163	In Stock
10 mg	$289	In Stock
25 mg	$578	In Stock
50 mg	$788	In Stock
100 mg	$1,120	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description	SGN-2FF is an oral fucosylation inhibitor and inhibits fucosyltransferase activity, and has antitumor activity.
In vitro	SGN-2FF is a fucosylation inhibitor, SGN-2FF inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of fucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.
In vivo	In multiple mouse tumor models, SGN-2FF exhibits antitumor activity. SGN-2FF shows substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.

Chemical Properties

Molecular Weight	166.15
Formula	C₆H₁₁FO₄
Cas No.	2089647-47-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 35 mg/mL (210.65 mM), Sonication is recommended.

DMSO: 50 mg/mL (300.93 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0187 mL	30.0933 mL	60.1866 mL	300.9329 mL
5 mM	1.2037 mL	6.0187 mL	12.0373 mL	60.1866 mL
10 mM	0.6019 mL	3.0093 mL	6.0187 mL	30.0933 mL
20 mM	0.3009 mL	1.5047 mL	3.0093 mL	15.0466 mL
50 mM	0.1204 mL	0.6019 mL	1.2037 mL	6.0187 mL
100 mM	0.0602 mL	0.3009 mL	0.6019 mL	3.0093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SGN 2FFinhibitSGN2FFInhibitorSGN-2FF