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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $81 | In Stock | |
10 mg | $129 | In Stock | |
25 mg | $277 | In Stock | |
50 mg | $445 | In Stock | |
100 mg | $689 | In Stock | |
500 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $115 | In Stock |
Description | STO-609 is a specific and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) for recombinant CaM-KKα/KKβ (Ki: 80/15 ng/mL). |
Targets&IC50 | CaM-KKβ:47 nM(Ki), CaM-KKα:0.25 μM(Ki) |
In vitro | STO-609 also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 dose-dependently suppresses the Ca2+-induced activation of CaM-KIV. STO-609 (1μg/mL) significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (80%). |
Alias | STO 609 |
Molecular Weight | 314.29 |
Formula | C19H10N2O3 |
Cas No. | 52029-86-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.17 mg/mL (13.26 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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